Fabrication of Engineered Drug-Polymer Composite Particles via Piezoelectric Inkjet Technique for Floating Drug Delivery Systems.

Autor:	Kim HJ; Department of Chemical Engineering (BK21 FOUR Integrated Engineering Program), Kyung Hee University, Yongin 17104, South Korea., Jang J; Department of Chemical Engineering (BK21 FOUR Integrated Engineering Program), Kyung Hee University, Yongin 17104, South Korea., Lee J; Department of Chemical Engineering (BK21 FOUR Integrated Engineering Program), Kyung Hee University, Yongin 17104, South Korea., Han CH; Department of Chemical Engineering (BK21 FOUR Integrated Engineering Program), Kyung Hee University, Yongin 17104, South Korea., Kim JW; School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea., Park BJ; Department of Chemical Engineering (BK21 FOUR Integrated Engineering Program), Kyung Hee University, Yongin 17104, South Korea.
Jazyk:	angličtina
Zdroj:	Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.
DOI:	10.1021/acs.langmuir.4c03556
Abstrakt:	This study presents a simple approach for fabricating low-density drug-polymer amorphous solid dispersions (ASDs) using a piezoelectric inkjet method, demonstrating potential applications for floating drug delivery systems (FDDS). By adjusting the ratio of two polymers, polylactic acid, and Eudragit RLPO, the floatability and drug release rate of the drug-polymer ASD particles can be easily manipulated. Kinetic model analyses have been conducted to interpret the drug release mechanism. This work offers a robust platform for exploring diverse polymer-drug combinations that are applicable to FDDS.
Databáze:	MEDLINE
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