Current smoking is related to severe damage in systemic lupus erythematosus patients.

Autor: Cosatti MA; Centro de Educación Médica e Investigaciones Clínicas, CEMIC 'Norberto Quirno', Buenos Aires, Argentina., Muñoz SA; Hospital General de Agudos Juan A. Fernández, Ciudad Autónoma de Buenos Aires, Argentina., Tamborenea MT; OMI, Ciudad Autónoma de Buenos Aires, Argentina., García M; HIGA San Martin, Ciudad de La Plata, Argentina., Curti A; Hospital de Clínicas José de San Martin, Ciudad Autónoma de Buenos Aires, Argentina., Cappuccio A; Hospital Cesar Milstein, Ciudad Autónoma de Buenos Aires, Argentina., Rillo O; Hospital Pirovano, Ciudad Autónoma de Buenos Aires, Argentina., Imamura PM; Hospital Italiano, Ciudad Autónoma de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina., Schneeberger E; Instituto de Rehabilitación Psicofísica (IREP), Ciudad Autónoma de Buenos Aires, Argentina., Dal Pra F; Instituto de Rehabilitación Psicofísica (IREP), Ciudad Autónoma de Buenos Aires, Argentina., Ballent M; Hospital Ramón Santamarina, Ciudad de Tandil, Argentina., Cousseau ML; Policlínica Privada Paz, Ciudad de Tandil, Argentina., Velasco Zamora J; Instituto Médico CER, Ciudad de Quilmes, Argentina., Saurit V; Hospital Privado Centro Médico de Córdoba, Ciudad de Córdoba, Argentina., Toloza S; Hospital Interzonal San Juan Bautista, Ciudad de San Fernando del Valle de Catamarca, Argentina., Danielsen MC; Consultorio de Reumatología, Ciudad de Santiago del Estero, Argentina., Bellomio VI; Centro Médico Privado de Reumatología, Ciudad de San Miguel de Tucumán, Argentina., Graf C; Centro Médico Mitre, Ciudad de Paraná, Argentina., Paira S; Hospital José Maria Cullen, Ciudad de Santa Fe, Argentina., Cavallasca J; Hospital José Bernardo Iturraspe, Ciudad de San Francisco, Argentina., Pons Estel B; Sanatorio Parque, Ciudad de Rosario, Argentina., Cristian Moreno JL; Instituto Médico CER, Ciudad de San Juan, Argentina., Díaz M; Centro Traumatológico Bariloche, Ciudad de San Carlos de Bariloche, Argentina., Alba P; Hospital de Córdoba, Ciudad de Córdoba, Argentina., Verando M; Hospital General de Agudos Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina., Tate G; OMI, Ciudad Autónoma de Buenos Aires, Argentina., Mysler E; OMI, Ciudad Autónoma de Buenos Aires, Argentina., Sarano J; Instituto de Investigaciones Médicas Dr Alfredo Lanari, Ciudad Autónoma de Buenos Aires, Argentina., Civit EE; Hospital Del Carmen, Ciudad de Godoy Cruz, Argentina., Risueño F; Itemédica, Ciudad de Bahía Blanca, Argentina., Álvarez Sepúlveda P; Hospital de San Isidro, Ciudad de San Isidro, Argentina., Larroude MS; Hospital Cesar Milstein, Ciudad Autónoma de Buenos Aires, Argentina., Méndez MF; Consultorios Pilar, Puerto Madryn, Argentina., Conforti A; OSEP Mendoza, Ciudad de Mendoza, Argentina., Sohn D; Instituto de Diagnóstico Roche, Ciudad de Escobar, Argentina., Helling CA; OMI, Ciudad Autónoma de Buenos Aires, Argentina., Roverano S; Hospital José Maria Cullen, Ciudad de Santa Fe, Argentina., Malm-Green S; Hospital General de Agudos Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina., Medina Bornachera D; Hospital Penna, Ciudad Autónoma de Buenos Aires, Argentina., Alvarez A; Hospital Penna, Ciudad Autónoma de Buenos Aires, Argentina., Eimon A; Centro de Educación Médica e Investigaciones Clínicas, CEMIC 'Norberto Quirno', Buenos Aires, Argentina., Pendón G; Hospital Ricardo Gutierrez La Plata, La Plata, Argentina., Mayer M; Hospital Britanico de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina., Marin J; Hospital Italiano, Ciudad Autónoma de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina., Pisoni CN; Centro de Educación Médica e Investigaciones Clínicas, CEMIC 'Norberto Quirno', Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Lupus [Lupus] 2025 Jan; Vol. 34 (1), pp. 28-33. Date of Electronic Publication: 2024 Nov 18.
DOI: 10.1177/09612033241301182
Abstrakt: Objective: To assess the relationship between smoking exposure and organ damage accrual measured by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for Systemic Lupus Erythematosus score (SLICC-SDI) in consecutive patients with systemic lupus erythematosus (SLE) from Argentina.
Methods: 623 consecutive SLE patients (fulfilling ≥4, 1997 ACR criteria) were included in this cross-sectional study. Sociodemographic and disease related variables including SLICC-SDI score and smoking status were collected. Patients currently smoking were considered "smokers", and "non-smokers" those who never smoked and former smokers. SLICC-SDI was divided into two categories: <3 and ≥3 was defined as severe damage.
Results: Six hundred and 23 patients were included in the analysis, 89% women. Eighty-four per cent were non-smokers and 16 % were current smokers 83 percent of patients had SLICC-SDI <3 and 17 % had SLICC-SDI ≥3. Twenty one percent of patients with SLICC-SDI ≥3 and 15% with <3 SLICC-SDI were current smokers ( p 0.081). In the multiple regression analysis, current smoking (OR 1.82, CI 95% 1.01-3.31, p 0.046), older age (OR 1.04, CI 95% 1.00-1.05, p 0.034), disease duration (OR 1.03, CI 95% 1.00-1.07, p 0.021) and cyclophosphamide exposure (OR 2.97, CI 95% 1.49-5.88, p 0.002) were related to SLICC-SDI ≥3.
Conclusion: In our sample of patients, current smoking, older age, disease duration and cyclophosphamide were related to severe damage (SLICC-SDI ≥3).
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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