Recommendations for Research to Develop a Patient-Centered Clinical Follow-Up Protocol for Oral Epithelial Dysplasia.

Autor: Güneri P; Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Ege University, Izmir, Turkiye., Bolukbasi G; Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Ege University, Izmir, Turkiye., Ilhan B; Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Ege University, Izmir, Turkiye., Epstein JB; City of Hope Comprehensive Cancer Center Duarte CA and Cedars Sinai Health System, Los Angeles, California, USA., Warnakulasuriya S; Faculty of Dental, Oral & Craniofacial Sciences, King's College London, and the WHO Collaborating Centre for Oral Cancer, London, UK.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.
DOI: 10.1002/hed.28001
Abstrakt: Oral epithelial dysplasia (OED) is the primary histological marker for assessing the progression of oral potentially malignant disorders (OPMDs) to cancer. Despite challenges in grading and low inter-pathologist reproducibility, OED severity remains the key predictor of malignant transformation. However, globally accepted guidelines for OED monitoring are lacking, despite calls for individualized management based on host and lesion characteristics. The proposed research protocol involves acquiring high-quality intraoral images, assessing oral hygiene and periodontal status, eliminating chronic mechanical irritation and Candida infections, and applying adjunctive diagnostic methods like toluidine blue staining, optical evaluation, and brush cytology. Tailored follow-up regimens based on individual risk assessments are emphasized, with frequent monitoring for high-grade dysplasia or patients at higher risk of progression. Therefore, effective OED management should consider the patient's immune status, dietary habits, and oral microbiota, aiming to develop personalized treatment strategies that optimize patient-centered care.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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