Electroconvulsive therapy generates a hidden wave after seizure.

Autor:	Rosenthal ZP; Psychiatry Residency Physician-Scientist Research Track, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Majeski JB; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA., Somarowthu A; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, PA, USA., Quinn DK; Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA., Lindquist BE; Department of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, USA., Putt ME; Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Karaj A; Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Favilla CG; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Baker WB; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, PA, USA., Hosseini G; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rodriguez JP; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cristancho MA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neuromodulation in Depression and Stress, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sheline YI; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Neuromodulation in Depression and Stress, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shuttleworth CW; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA., Abbott CC; Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA., Yodh AG; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA., Goldberg EM; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, PA, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 01. Date of Electronic Publication: 2024 Nov 01.
DOI:	10.1101/2024.10.31.621357
Abstrakt:	Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the underlying neurobiology is understudied and remains largely unresolved. Using optical neuroimaging to probe neural activity and hemodynamics in a mouse model of ECT, we demonstrated that a second brain event follows seizure: cortical spreading depolarization (CSD). We further found that ECT stimulation pulse parameters and electrode configuration directly shaped the wave dynamics of seizure and subsequent CSD. To translate these findings to human patients, we tested for the presence of hemodynamic signatures of post-ictal CSD using non-invasive diffuse optical monitoring of cerebral blood flow and oxygenation during routine ECT treatments. We found evidence that humans generate hyperemic waves after ECT seizure which are highly consistent with CSD. These results challenge a long-held assumption that seizure is the primary outcome of ECT and point to new opportunities for optimizing ECT stimulation parameters to precisely modulate brain activity and treatment outcomes. Competing Interests: Competing Interests: No financial conflicts or completing interests to disclose.
Databáze:	MEDLINE
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