| Autor: |
Matityahu L, Hobel ZB, Berkowitz N, Malgady JM, Gilin N, Plotkin JL, Goldberg JA |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Dec 11. Date of Electronic Publication: 2024 Dec 11. |
| DOI: |
10.1101/2024.11.03.621726 |
| Abstrakt: |
Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the range of local serotonin release via a similar mechanism. This process is exaggerated in the hypercholinergic striatum of a mouse model of OCD-like behavior, implicating CINs as critical regulators of serotonin levels in the healthy and pathological striatum. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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