Effect of vitamin C injections on exercise muscular performance and biochemical parameters in Trichinella spiralis -infected mice.

Autor:	Rashed HAE; Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt., Albogami B; Department of Biology, College of Sciences, Taif University, Taif, Saudi Arabia., Alkhaldi AAM; Department of Biological Sciences, College of Science, Jouf University, Sakaka, Saudi Arabia., Abuzinadah NY; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia., Abuzahrah SS; Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia., Al-Salmi FA; Department of Biology, College of Sciences, Taif University, Taif, Saudi Arabia., Fayad E; Department of Biotechnology, College of Sciences, Taif University, Taif, Saudi Arabia., Fouad RM; Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt., Fikry ME; Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt., ElSaey AA; Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt., Abu Almaaty AH; Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2024 Nov 13; Vol. 12, pp. e18381. Date of Electronic Publication: 2024 Nov 13 (Print Publication: 2024).
DOI:	10.7717/peerj.18381
Abstrakt:	Background: Trichinella spiralis is a worldwide intestinal nematode that can parasitize the striated muscles of its hosts at the larval stage. This study aims to evaluate potential of vitamin C for treating trichinellosis-related pathological problems in the infected muscles of mice. Materials and Methods: Thirty CD1 male Albino mice were divided into three groups (10 mice per group). Negative and positive control groups (0.9% NaCl) and the infected vitamin C group (10 mg/kg body weight). Two weeks post-infection, each group was intraperitoneally injected daily for two weeks with Vitamin C or saline. The performance of the muscles was assessed both before and after the treatment. After dissection, constant parts of striated muscles were removed for further assays. The scoring of the histological changes of infected muscles was carried out. In addition to muscle malondialdehyde levels, superoxide dismutase and catalase activities were measured for the oxidative and antioxidant states. Creatine kinase and aspartate aminotransferase were also measured in tissues to reflect the degree of muscular damage. Results: Vitamin C enhances the weakness of the muscular performance resulting from the infection. Vitamin C was able to repair some of the histological lesions that resulted from the infection. Trichinellosis caused severe changes in the biochemical markers in positive control animals. Muscle damage biomarkers and, besides, oxidative and antioxidant conditions were greatly ameliorated in infected vitamin C animals. Summing up, vitamin C can be used as a complementary drug due to its efficiency in improving pathogenesis following a trichinellosis infection. The supplement also must be tested in the intestinal stage of infection after showing promising results in the muscular stage. Competing Interests: The authors declare there are no competing interests. (©2024 Rashed et al.)
Databáze:	MEDLINE
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