The house cricket is an unrecognized but potentially powerful model for aging intervention studies.
| Autor: | Liao GY; Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA., Rosenfeld M; Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA., Wezeman J; Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA., Ladiges W; Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Aging pathobiology and therapeutics [Aging Pathobiol Ther] 2024; Vol. 6 (1), pp. 39-41. Date of Electronic Publication: 2024 Mar 28. |
| DOI: | 10.31491/apt.2024.03.135 |
| Abstrakt: | Human-based research on the biology of aging poses challenges due to ethical, social, and cost considerations. Animal models offer a pragmatic alternative, although no single model fully replicates all aspects of human aging. One unexplored model for studying aging is the house cricket ( Acheta domesticus ). House crickets present advantages for aging intervention research, such as consuming an omnivorous diet, availability on a heterogeneous genetic background, short lifespan, and simple but well-defined organ systems. In a preliminary experiment, the effects of flax oil, which is rich in omega-3 fatty acids, on the lifespan of house crickets were investigated. Cold-pressed flax oil was added as a 10% mixture to moist guinea pig chow mash and fed to crickets starting at 8 weeks of age and continuing for 11 weeks until the last cricket died. Results demonstrated a significant extension in survival of crickets fed the flax oil diet, further emphasizing the low cost, simplicity, and short time required to conduct dietary intervention studies in house crickets. Using this observation as a prototype, the house cricket is a promising and deserving model for interventional drug testing based on an aging platform. Competing Interests: Conflicts of interest: Warren Ladiges is a member of the editorial board of Aging Pathobiology and Therapeutics. The authors declare that they have no conflicts and were not involved in the journal’s review or decision regarding this manuscript. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|