Electronic relaxation pathways in thio-acridone and thio-coumarin: two heavy-atom-free photosensitizers absorbing visible light.

Autor:	Acquah C; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. cxc302@case.edu., Hoehn S; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. cxc302@case.edu., Krul S; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. cxc302@case.edu., Jockusch S; Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, 43403, USA., Yang S; Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas, 77005, USA., Seth SK; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. cxc302@case.edu., Lee E; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. cxc302@case.edu., Xiao H; Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas, 77005, USA.; Department of Biosciences, Rice University, 6100 Main Street, Houston, Texas, 77005, USA.; Department of Bioengineering, Rice University, 6100 Main Street, Houston, Texas, 77005, USA.; SynthX Center, Rice University, 6100 Main Street, Houston, Texas, 77005, USA., Crespo-Hernández CE; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. cxc302@case.edu.
Jazyk:	angličtina
Zdroj:	Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.
DOI:	10.1039/d4cp03720k
Abstrakt:	Heavy-atom-free photosensitizers (HAF-PSs) have emerged as a new class of photosensitizers aiming to broaden their applicability and versatility across various fields of the photodynamic therapy of cancers. The strategy involves replacing the exocyclic oxygen atoms of the carbonyl groups of established biocompatible organic fluorophores with sulfur, thereby bathochromically shifting their absorption spectra and enhancing their intersystem crossing efficiencies. Despite these advancements, the photophysical attributes and electronic relaxation mechanisms of many of these HAF-PSs remain inadequately elucidated. In this study, we investigate the excited state dynamics and photochemical properties of two promising HAF-PSs, thio-coumarin and thio-acridone. Employing a combination of steady-state and time-resolved techniques from femtoseconds to microseconds, coupled with quantum chemical calculations, we unravel the electronic relaxation mechanisms that give rise to the efficient population of long-lived and reactive triplet states in these HAF-PSs.
Databáze:	MEDLINE
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