Evaluation of Carotid Stenosis in a High-Stroke-Risk Population by Hemodynamic Dual-Parameters Based on Ultrasound Vector Flow Imaging.

Autor: Hong S; Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Dong Y; Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Gao W; Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Song D; Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Liu M; Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Li W; Department of Radiology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Du Y; Ultrasound R&D Department, Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen, Guangdong, China., Xu J; Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Dong F; Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Jazyk: angličtina
Zdroj: Brain and behavior [Brain Behav] 2024 Nov; Vol. 14 (11), pp. e70150.
DOI: 10.1002/brb3.70150
Abstrakt: Objective: This study explored the feasibility of using high-frame-rate ultrasound vector flow imaging (VFI) to quantitatively assess hemodynamics in atherosclerotic internal carotid artery stenosis (ICAS) by evaluating dual-parameters, turbulence index (Tur), and wall shear stress (WSS). Their efficacy in evaluating carotid artery stenosis was also analyzed.
Methods: Fifty-nine patients with ICAS were enrolled. B-mode ultrasound and V Flow (a high-frame-rate VFI) were performed using the Resona R9 system. The stenosis rate was measured in grayscale mode, whereas the time-averaged Tur index, the time-averaged WSS (WSS mean ), and maximum WSS (WSS max ) around stenosis were measured. The combined diagnostic efficacy of Tur inand WSS was also investigated.
Results: Compared to proximal to stenosis (Tur index, 2.88% ± 3.65%), highly disordered blood flow was observed in the stenotic (23.17% ± 15.52%, p < 0.001) and distal segment (25.86% ± 17.29%, p < 0.001). WSS max ([11.91 ± 6.73] vs. [4.43 ± 5.4] Pa, p < 0.001) and WSS mean ([3.42 ± 2.67] vs. [0.86 ± 1.21] Pa, p < 0.001) were significantly bigger in stenotic than those in the distal segment. The differences in the ratio WSS max /Tur or WSS mean /Tur among different segments around stenosis were statistically significant (p < 0.001). The combination of Tur index and WSS had the best diagnostic performance in ICAS (AUC, 0.899).
Conclusion: The application of Tur index and WSS for quantitative assessment of ICAS hemodynamic changes is feasible, with the combined evaluation of these two parameters providing incremental diagnostic value for carotid artery stenosis. VFI-based dual quantitative parameters may offer promising noninvasive diagnostic tools for carotid artery stenosis in high-stroke-risk populations.
(© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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