Associations of life-course cardiovascular risk factors with late-life cerebral haemodynamics.

Autor:	Dijsselhof MB; Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit, NL.; Amsterdam Neuroscience, Brain Imaging, NL., Holtrop J; Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit, NL.; Amsterdam Neuroscience, Brain Imaging, NL., James SN; MRC Unit for Lifelong Health and Ageing at UCL, University College London, UK., Sudre CH; MRC Unit for Lifelong Health and Ageing at UCL, University College London, UK.; Centre for Medical Image Computing, Department of Computer Science, University College London, UK.; Department of Biomedical Computing, School of Biomedical Engineering & Imaging Sciences, King's College London, UK., Lu K; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK., Lorenzini L; Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit, NL.; Amsterdam Neuroscience, Brain Imaging, NL., Collij LE; Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit, NL.; Amsterdam Neuroscience, Brain Imaging, NL.; Clinical Memory Research Unit (R.O.), Lund University, Sweden., Scott CJ; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Institute of Nuclear Medicine, University College London Hospital NHS Foundation Trust, London, UK., Manning EN; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK., Thomas DL; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK., Richards M; MRC Unit for Lifelong Health and Ageing at UCL, University College London, UK., Hughes AD; MRC Unit for Lifelong Health and Ageing at UCL, University College London, UK., Cash DM; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute at University College London., Barkhof F; Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit, NL.; Amsterdam Neuroscience, Brain Imaging, NL.; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, UK., Schott JM; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK., Petr J; Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit, NL.; Amsterdam Neuroscience, Brain Imaging, NL.; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, DE., Mutsaerts HJ; Dept. of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit, NL.; Amsterdam Neuroscience, Brain Imaging, NL.
Jazyk:	angličtina
Zdroj:	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2024 Nov 17, pp. 271678X241301261. Date of Electronic Publication: 2024 Nov 17.
DOI:	10.1177/0271678X241301261
Abstrakt:	While the associations of mid-life cardiovascular risk factors with late-life white matter lesions (WMH) and cognitive decline have been established, the role of cerebral haemodynamics is unclear. We investigated the relation of late-life (69-71 years) arterial spin labelling (ASL) MRI-derived cerebral blood flow (CBF) with life-course cardiovascular risk factors (36-71 years) and late-life white matter hyperintensity (WMH) load in 282 cognitively healthy participants (52.8% female). Late-life (69-71 years) high systolic (B = -0.15) and diastolic (B = -0.25) blood pressure, and mean arterial pressure (B = -0.25) were associated with low grey matter (GM) CBF (p < 0.03), and white matter CBF (B = -0.25; B = -0.15; B = -0.13, p < 0.03, respectively). The association between systolic blood pressure and GM CBF differed between sexes (male/female B = -0.15/0.02, p = 0.04). No associations were found with early- or mid-life cardiovascular risk factors. Furthermore, WMHs were associated with cerebral haemodynamics but not cardiovascular risk factors. These findings suggest that cerebral blood flow autoregulation is able to maintain stable global cerebral haemodynamics until later in life. Future studies are encouraged to investigate why cardiovascular risk factors have differential effects on haemodynamics and WMH, and their implications for cognitive decline. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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