Obstructive sleep apnoea and lung function, and their association with nocturnal hypoxemia: results from the Swedish CArdioPulmonary bioimage Study (SCAPIS) - a cross-sectional study.
| Autor: | Delshad B; Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, Sweden baz.delshad@medsci.uu.se., Ljunggren M; Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, Sweden., Zhou XW; Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, Sweden., Theorell-Haglöw J; Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, Sweden., Janson C; Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, Sweden., Zou D; Center for Sleep and Vigilance Disorders, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden., Hedner J; Center for Sleep and Vigilance Disorders, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden., Grote L; Centre for Sleep and Wake Disorders, Sahlgrenska Academy, Goteborgs Universitet, Goteborg, Sweden., Blomberg A; Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umea, Sweden., Franklin K; Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umea, Sweden., Sahlin C; Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umea, Sweden., Malinovschi A; Department of Medical Sciences, Clinical Physiology, Uppsala University Faculty of Medicine, Uppsala, Sweden., Lindberg E; Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ open [BMJ Open] 2024 Nov 17; Vol. 14 (11), pp. e086596. Date of Electronic Publication: 2024 Nov 17. |
| DOI: | 10.1136/bmjopen-2024-086596 |
| Abstrakt: | Obstructive sleep apnoea (OSA) and its associations with lung function. Background: OSA is highly prevalent and characterised by abnormal respiration during sleep. This large, population-based study aimed to investigate the associations between OSA and lung function in subjects aged 50-64 years. Method: The population-based Swedish CArdioPulmonary bioimage Study includes information on anthropometry, comorbidities and spirometry. The current analysis included data from three centres (Gothenburg, Umeå and Uppsala) on whole-night respiratory polygraphy as a meta-analysis examining the overall effect size of lung function on sleep apnoea severity, expressed as ß-coefficient after stratifying for sex and adjusting for age, waist circumference and smoking status. Results: Data from 9016 participants (54% women, age 58±4 years, body mass index 27±4 kg/m 2 ) with sleep recordings of good quality were included in the final analysis. Forced expiratory volume during 1 s (FEV Conclusion: In OSA, lower lung function is more distinctly associated with the nocturnal hypoxic burden than AHI. Potential lung function impairment should be investigated in OSA patients with a high ODI relative to AHI. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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