Changes in fatty acid intake and subsequent risk of all-cause and cause-specific mortality in males and females: a prospective cohort study.
| Autor: | Liu Y; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Departments of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA., Gu X; Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA., Li Y; Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA., Rimm EB; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Departments of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA., Willett WC; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Departments of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA., Stampfer MJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Departments of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA., Hu FB; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Departments of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA. Electronic address: fhu@hsph.harvard.edu., Wang DD; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA. Electronic address: dow471@mail.harvard.edu. |
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| Jazyk: | angličtina |
| Zdroj: | The American journal of clinical nutrition [Am J Clin Nutr] 2024 Nov 15. Date of Electronic Publication: 2024 Nov 15. |
| DOI: | 10.1016/j.ajcnut.2024.11.012 |
| Abstrakt: | Background: The associations between changes in fatty acid intake over time and subsequent mortality are unclear. Objective: To prospectively examine associations between changes in fatty acid intake (as percentage of total energy) and mortality. Methods: Among 65,179 adults from the Nurses' Health Study and Health Professionals Follow-up Study, free from cardiovascular disease, cancer, and diabetes at baseline in 1994, we documented 20,571 deaths through 2020 (1,334,603 person-years). Diets were assessed every four years using validated questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality risk were estimated from Cox proportional hazards models. Results: A 5% of energy increment in total fat intake was associated with 5% lower all-cause mortality (HR =0.95; 95% CI: 0.93, 0.96; isocaloric comparison was total carbohydrate). The HRs of all-cause mortality (95% CI) were 0.83 (0.78, 0.89) and 0.91 (0.87, 0.94) for 5% increment in energy intake from polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid (MUFA), respectively, and was 1.10 (1.04, 1.17) for a 1% increase in energy intake from trans fatty acid (TFA; all P Conclusions: These findings support replacing SFA with unsaturated fatty acids (especially from plant sources) and eliminating dietary TFA to reduce premature death. Competing Interests: Declaration of Competing Interest ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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