Neuroprotective effects of nutraceuticals and natural products in Traumatic Brain Injury.

Autor: Bhargavi KM; Department of Clinical Psychopharmacology and Neurotoxicology (CPNT), National Institute of Mental Health and Neurosciences (NIMHANS), No. 2900, Hosur Road, Bangalore-560029, INDIA; Department of Human Genetics, NIMHANS, No. 2900, Hosur Road, Bangalore-560029, INDIA., Gowthami N; Department of Clinical Psychopharmacology and Neurotoxicology (CPNT), National Institute of Mental Health and Neurosciences (NIMHANS), No. 2900, Hosur Road, Bangalore-560029, INDIA., Chetan GK; Department of Human Genetics, NIMHANS, No. 2900, Hosur Road, Bangalore-560029, INDIA., Bharath MMS; Department of Clinical Psychopharmacology and Neurotoxicology (CPNT), National Institute of Mental Health and Neurosciences (NIMHANS), No. 2900, Hosur Road, Bangalore-560029, INDIA; Center for neurobehavioural toxicology, Department of CPNT, NIMHANS, No. 2900, Hosur Road, Bangalore-560029, INDIA. Electronic address: bharath@nimhans.ac.in.
Jazyk: angličtina
Zdroj: Neurochemistry international [Neurochem Int] 2024 Nov 15, pp. 105904. Date of Electronic Publication: 2024 Nov 15.
DOI: 10.1016/j.neuint.2024.105904
Abstrakt: Traumatic Brain Injury (TBI) is a global healthcare concern with considerable mortality and morbidity. Early diagnosis and timely treatment are critical for optimal clinical prognosis in TBI patients. Injury to the brain tissue following TBI is categorized into primary and secondary injury events, with the former being acute, while the latter evolves over a long period. Although surgical intervention is effective to treat primary injury, secondary injury events that could contribute to long term neurological deterioration, cognitive impairment and neurodegeneration do not have appropriate pharmacotherapy. To address this lacuna, studies based on modern medicine to explore novel drugs in TBI have met with limited success. This has led to focussed efforts to assess natural products capable of targeting multiple pathways in TBI. Complex natural mixtures and isolated phytochemicals capable of targeting redox mechanisms, neuroinflammation, mitochondrial dysfunction, cell death pathways and other specific targets etc. have been characterized. However, the field has met with certain limitations and challenges with inadequate clinical studies and trials being the most important concern. The current review provides an overview of the dietary factors, nutraceuticals, natural extracts, and phytochemicals that could be potentially applied in neuroprotection, TBI therapy and long-term management of cognitive symptoms and other neurological deficits.
Competing Interests: Declaration of Competing Interest: None
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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