Markers of Environmental Enteric Dysfunction Are Associated with Poor Growth and Developmental Outcomes among Young Children in Lusaka, Zambia.

Autor: Lauer JM; Department of Health Sciences, Sargent College of Health & Rehabilitation Sciences, Boston University, Boston, MA, USA. Electronic address: jmlauer@bu.edu., Pyykkö J; Department of Global Health, Boston University School of Public Health, Boston, MA, USA., Chembe M; Innovations for Poverty Action Zambia, Lusaka, Zambia., Bilima-Mulenga T; Innovations for Poverty Action Zambia, Lusaka, Zambia., Sikazwe D; Ministry of Health, Lusaka, Zambia., Chibwe B; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Henderson S; Innovations for Poverty Action, Washington DC, USA., Parkerson D; Innovations for Poverty Action, Washington DC, USA., Leppänen JM; Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland., Fink G; University of Basel and Swiss Tropical and Public Health Institute, Basel, Switzerland., Locks LM; Department of Health Sciences, Sargent College of Health & Rehabilitation Sciences, Boston University, Boston, MA, USA and Department of Global Health, Boston University School of Public Health, Boston, MA, USA., Rockers PC; Department of Global Health, Boston University School of Public Health, Boston, MA, USA.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2024 Nov 15, pp. 114408. Date of Electronic Publication: 2024 Nov 15.
DOI: 10.1016/j.jpeds.2024.114408
Abstrakt: Objective: To examine cross-sectional relationships between biomarkers of environmental enteric dysfunction (EED), an acquired subclinical condition of the small intestine, and anthropometric and developmental outcomes among children in Lusaka, Zambia.
Study Design: Serum samples were collected from 240 children ages 27 to 35 months enrolled in a cluster-randomized trial assessing the effects of growth charts and small-quantity lipid-based nutrient supplements on linear growth. Samples were analyzed using the 11-plex Micronutrient and EED Assessment Tool, which incorporates two biomarkers of EED, namely intestinal fatty acid-binding protein (I-FABP), a marker of epithelial damage, and soluble CD14 (sCD14), a marker of microbial translocation. Associations between log 2 -transformed biomarker concentrations and anthropometric (height-for-age z-score [HAZ], weight-for-height z-score, and weight-for-age z-score0 and developmental (Global Scales of Early Development [GSED] development for age z-score [DAZ] and saccadic reaction time [SRT]) outcomes were assessed using linear regression analyses adjusted for background characteristics.
Results: Mean ± SD HAZ was -1.94 ± 1.10. Higher sCD14 and I-FABP concentrations were significantly associated with lower HAZ (β: -0.21, 95% CI: -0.41, -0.01 and β: -0.20, 95% CI: -0.32, -0.08, respectively). Higher I-FABP concentrations were significantly associated with lower DAZ (β: -0.22, 95% CI: -0.40, -0.03) and slower SRT (β: 7.37 ms, 95% CI: 2.02, 12.72) as were higher alpha-1-acid glycoprotein concentrations (HAZ β: -0.38, 95% CI: -0.72, -0.03; SRT β: 11.14 ms, 95% CI: 0.94, 21.72).
Conclusions: In children in Lusaka, biomarkers of EED were associated with poor anthropometric and developmental outcomes, underscoring the need for interventions to address EED to improve child health globally.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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