Intrinsic versus extrinsic contribution to intraindividual sweat rate variability of individual eccrine glands.

Autor: Woolf EK; School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America; Reproductive Endocrinology and Women's Health Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States of America., Wells N; School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America., Moore J; School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America; The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA 90502, United States of America. Electronic address: jmoore714@gmail.com., Northway S; School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America., Buono MJ; School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, United States of America; Department of Biology, San Diego State University, San Diego, CA 92182, United States of America.
Jazyk: angličtina
Zdroj: Autonomic neuroscience : basic & clinical [Auton Neurosci] 2024 Dec; Vol. 256, pp. 103218. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1016/j.autneu.2024.103218
Abstrakt: The purpose of the current study was twofold. First, to determine the intraindividual variability of sweat rate per gland for a given skin location during exercise in the heat. Second, to determine the relative importance of intrinsic vs. extrinsic factors as the source of the intraindividual variability in the sweat rate per gland. Sweat rate of individual eccrine glands on the forearm was measured following pilocarpine iontophoresis and during exercise in the heat. In five participants during exercise in the heat, the measured sweat rate for individual forearm eccrine glands (n = 500) ranged from 0.5 nL/gland/min to 16 nL/gland/min, or over a 30-fold difference. The mean (SD) intraindividual coefficient of variation in sweat rate per gland was 36 (5)% and 49 (10)% (p = 0.008) following pilocarpine iontophoresis and during exercise in the heat, respectively. Such results suggest that intrinsic factors (i.e., sweat gland size and cholinergic sensitivity) contribute approximately three times more than extrinsic factors (i.e., sweat gland nerve fiber density and threshold amplitude) towards explaining the large intra-person variability in sweat rate per gland seen during exercise in the heat.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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