The impact of gut microbiome and diet on post-acute sequelae of SARS-CoV-2 infection.

Autor: Reyes Z; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America., Stovall MC; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America., Punyamurthula S; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America., Longo M; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America., Maraganore D; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America; Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, United States of America; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, United States of America., Solch-Ottaiano RJ; Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, United States of America; Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, United States of America; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, United States of America. Electronic address: rsolch@tulane.edu.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2024 Dec 15; Vol. 467, pp. 123295. Date of Electronic Publication: 2024 Nov 10.
DOI: 10.1016/j.jns.2024.123295
Abstrakt: Long COVID, also known as Post COVID-19 condition by the World Health Organization or Post-Acute Sequelae of SARS-CoV-2 infection (PASC), is defined as the development of symptoms such as post-exertional malaise, dysgeusia, and partial or full anosmia three months after initial SARS-CoV-2 infection. The multisystem effects of PASC make it difficult to distinguish from its mimickers. Further, a comprehensive evaluation of the gut microbiome, nutrition, and PASC has yet to be studied. The gut-brain axis describes bidirectional immune, neural, endocrine, and humoral modulatory interactions between the gut microbiome and brain function. We explore recent studies that support an association between alterations in gut microbiome diversity and the severity of acute-phase COVID-19, and how these may be affected by diets rich in antioxidants and fiber. The Mediterranean Diet (MeDi) has demonstrated promising neuroprotective effects through its anti-inflammatory processes. Further, diets rich in fiber increase gut diversity and increase the amount of short-chain fatty acids (SCFAs) within the body-both shown to protect from acute COVID-19 complications. Long-term changes to the gut microbiome persist after acute infection and may increase susceptibility to PASC. This study builds on existing knowledge of determinants of PASC and highlights a relationship between nutrition, gut microbiome, acute-phase COVID-19, and, subsequently, PASC susceptibility.
Competing Interests: Declaration of competing interest The authors have no competing interests to disclose.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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