Adverse drug reactions and its associated factors among geriatric hospitalized patients at selected comprehensive specialized hospitals of the Amhara Region, Ethiopia: a multicenter prospective cohort study.

Autor: Dagnew SB; Department of Clinical Pharmacy, College Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. samuelberihun12@gmail.com., Moges TA; Department of Clinical Pharmacy, College Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Ayele TM; Department of Pharmacology and Toxicology, College Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Wondm SA; Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Yazie TS; Department of Pharmacology and Toxicology, College Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Dagnew FN; Department of Clinical Pharmacy, College Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Jazyk: angličtina
Zdroj: BMC geriatrics [BMC Geriatr] 2024 Nov 16; Vol. 24 (1), pp. 955. Date of Electronic Publication: 2024 Nov 16.
DOI: 10.1186/s12877-024-05515-y
Abstrakt: Background: Adverse drug reactions are more prevalent in geriatric patients and are frequently associated with a range of polypharmacy-related issues as well as some physiological aging-related alterations. These affect the pharmacokinetic and pharmacodynamic properties of drugs. This study aimed to assess the magnitude of ADRs and their contributing factors among geriatric patients admitted at Comprehensive Specialized Hospitals of the Amhara Region.
Methods: A multicenter prospective cohort study was carried out from May 2023 to August 2023 on geriatric patients admitted to four randomly selected comprehensive hospitals in the Amhara region. We used logistic regression to find the factors influencing the occurrence of ADRs. A P value of less than 0.05 was deemed statistically significant.
Results: During the study's follow-up period, 373 patients in total were included. An incidence rate of 31.10% (95% CI: 26.38-35.82) was obtained from the identification of 121 ADRs in total. The organ most frequently affected by ADRs was the gastrointestinal tract (28.92%), followed by the cardiovascular system (19.01%), and the drug class most often implicated in ADRs was antibiotics (21.49%), then anticoagulants (12.40%). ADRs were substantially linked to being overweight (P < 0.001), having been hospitalized in the previous six months (P = 0.000), and hyperpolypharmacy (p = 0.047). 93.39% of all ADRs received the interventions. 85.12% of the adverse drug reactions were successfully resolved.
Conclusions: This study found that over one-third of older people and individuals admitted to the hospital experienced ADRs. Overweight, hyperpolypharmacy, and patients who had previously been admitted during the preceding six months were significantly linked with the occurrence of ADRs. Improving the drug safety of elderly patients, particularly those who are admitted, should be a greater priority for healthcare professionals.
Competing Interests: Declarations Ethics approval and consent to participate The ethical review committee of Debre Tabor University’s College of Health Science, Department of Pharmacy has approved ethical authorization with reference number 058/2023. A support letter was sent to each of the four comprehensive hospitals. The directors of those healthcare organizations were then asked to sign a letter approving the usage of patient records as a source of data. Participants were informed about the purpose and design of the study before data collection. Furthermore, they provided their official consent to participate in the research. Written informed consent was obtained from all the study participants. Patients’ medical registration numbers (MRNs) were swapped out for new codes during the data collecting and entry process. Besides, to protect its confidentiality, the gathered data was similarly kept in a locked cabinet and on a computer with a strong password. The study followed Helsinki legislation in terms of doing it in a properly anonymous and confidential manner. Consent for publication Not applicable. Competing interests The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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