Comparisons between Caucasian-validated and Chinese-validated photo-numeric scales for assessing facial wrinkles.

Autor: Ng JY; Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore., Zhou H; Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore., Li T; Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore., Chew FT; Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore. dbscft@nus.edu.sg.; Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, Lower Kent Ridge Road, Singapore, 117543, Singapore. dbscft@nus.edu.sg.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 16; Vol. 14 (1), pp. 28293. Date of Electronic Publication: 2024 Nov 16.
DOI: 10.1038/s41598-024-78945-8
Abstrakt: Skin ageing results in wrinkling. In this study, we discuss four types of facial wrinkles: Crow's Feet wrinkles, forehead wrinkles, glabellar frown wrinkles, and nasolabial folds. These four phenotypes can be assessed either with a photo-numeric scale developed and validated on Caucasian skin (i.e., Caucasian scale) or with a photo-numeric scale developed and validated on Chinese skin (i.e., Chinese scale). As Caucasian and Chinese skin have inherent differences, the main objective of this study is to determine whether these inherent differences affect the suitability of evaluating facial wrinkles on ethnic Chinese skin with a Caucasian scale. Three trained assessors studied four types of wrinkles on the faces of 1,081 ethnic Chinese young adults from the Singapore/Malaysia Cross-sectional Genetics Epidemiology Study (SMCGES). We found that Caucasian scales and Chinese scales are concordant (Spearman's Rank Correlation (ρ) values: 0.53-0.80) and the level of agreement between the Caucasian scales and Chinese scales is moderately high (Cohen's Kappa (κ) values: 0.40-0.49). When tested on ethnic Chinese skin, both the Caucasian scale and the Chinese scale are largely consistent in showing presence or absence of a given facial wrinkle (Area under curve (AUC) values: 0.79-0.90). All assessors are highly internally consistent (Weighted Kappa (κ w ) values: 0.686-0.992). Our results build confidence that four types of facial wrinkles on ethnic Chinese faces can be assessed with Caucasian scales. To the best of our knowledge, Chinese scales for facial wrinkles beyond the four types discussed here have yet to be developed. Caucasian scales for these other facial wrinkles will also need to be tested for their suitability to be used on ethnic Chinese skin as and when more Chinese scales are developed.
Competing Interests: Declarations Ethics approval and consent This study was conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practices, and in compliance with local regulatory requirements. The cross-sectional studies in Singapore were conducted on the National University of Singapore (NUS) campus annually between 2005 and 2023 with the approval of the Institutional Review Board (Reference Code: NUS-07-023, NUS-09-256, NUS-10-445, NUS-13-075, NUS-14-150, and NUS-18-036) and by the Helsinki declaration, of which, participants between 2011 and 2022 participated in the current skin ageing study (Reference Code: NUS-2020-495). The cross-sectional studies in Malaysia were held in Universiti Tunku Abdul Rahman (UTAR) Campus and Sunway University. Ethical approval was granted from the Scientific and Ethical Review Committee of UTAR (Reference Code: U/SERC/03/2016) and the Sunway University Research Ethics Committee (Reference Code: SUREC 2019/029 and SUREC 2022/049). Before the data collection, all participants involved signed an informed consent form. Consent for publication All authors have read and consented to the publication of this manuscript. Competing interests F.T.C reports grants from the National University of Singapore, Singapore Ministry of Education Academic Research Fund, Singapore Immunology Network, National Medical Research Council (NMRC) (Singapore), Biomedical Research Council (BMRC) (Singapore), National Research Foundation (NRF) (Singapore), Singapore Food Agency (SFA), Singapore’s Economic Development Board (EDB), and the Agency for Science Technology and Research (A*STAR) (Singapore), during the conduct of the study; and consulting fees from Sime Darby Technology Centre; First Resources Ltd; Genting Plantation, Olam International, Musim Mas, and Syngenta Crop Protection, outside the submitted work. The other authors declare no other competing interests. This research is supported by the National Research Foundation Singapore under its Open Fund-Large Collaborative Grant (MOH-001636) (A-8002641-00-00) and administered by the Singapore Ministry of Health’s National Medical Research Council.
(© 2024. The Author(s).)
Databáze: MEDLINE
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