Bufadienolides from Helleborus foetidus and their cytotoxic properties on MCF-7 breast cancer cells.
| Autor: | Potterat O; Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH-4056, Basel, Switzerland. Electronic address: olivier.potterat@unibas.ch., Kaufmann M; Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH-4056, Basel, Switzerland., Tschopp C; Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH-4056, Basel, Switzerland., Caj M; Institute for Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, CH-4132, Muttenz, Switzerland., Reinhardt JK; Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH-4056, Basel, Switzerland., Prescimone A; University of Basel, Department of Chemistry, Mattenstrasse 22, CH-4058, Basel, Switzerland., Shah D; Iscador AG, Kirschweg 9, CH-4144, Arlesheim, Switzerland; Association for Cancer Research, Hiscia Institute, Kirschweg 9, CH-4144, Arlesheim, Switzerland., Baumgartner S; Association for Cancer Research, Hiscia Institute, Kirschweg 9, CH-4144, Arlesheim, Switzerland; Institute for Integrative Medicine, University of Witten/Herdecke, Gerhard-Kienle-Weg 4, D-58313, Herdecke, Germany., Sciotti MA; Institute for Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, CH-4132, Muttenz, Switzerland., Suter-Dick L; Institute for Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, CH-4132, Muttenz, Switzerland. |
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| Jazyk: | angličtina |
| Zdroj: | Phytochemistry [Phytochemistry] 2025 Feb; Vol. 230, pp. 114329. Date of Electronic Publication: 2024 Nov 15. |
| DOI: | 10.1016/j.phytochem.2024.114329 |
| Abstrakt: | Twelve bufadienolides and six 19-norbufadienolides were isolated from the aerial parts of Helleborus foetidus. They consist of aglycons and glucosides and include nine previously undescribed compounds and a compound reported for the first time as a genuine natural product. Their structures were established by extensive spectroscopic analysis and the structure and absolute configuration of two previously unreported 3,4-epoxy derivatives were confirmed by single crystal X-ray diffraction analysis. The compounds were tested for their cytotoxicity on MCF-7 human breast cancer cells. They show differential cytotoxic activity with IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Databáze: | MEDLINE |
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