Prolamin and prolamin-polysaccharide composite nanoparticles for oral drug and nutrient delivery systems: A review.

Autor: Huang S; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, PR China., Li Y; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310012, PR China., Sun S; Research Institute of Food and Agriculture Nutrition, Standard Investment (China) Ltd., No. 2138 Wanyuan Rd, Shanghai 201103, PR China., Liu TC; Research Institute of Food and Agriculture Nutrition, Standard Investment (China) Ltd., No. 2138 Wanyuan Rd, Shanghai 201103, PR China., Xiao Q; Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, PR China. Electronic address: qi.xiao@nnnu.edu.cn., Zhang Y; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310012, PR China. Electronic address: zhangyue@zjgsu.edu.cn.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Nov 14; Vol. 283 (Pt 1), pp. 137567. Date of Electronic Publication: 2024 Nov 14.
DOI: 10.1016/j.ijbiomac.2024.137567
Abstrakt: Prolamin-based nanoparticles, particularly those composed of prolamin-polysaccharide composites, have garnered significant interest as oral delivery systems in recent research. This review provides a thorough analysis of the current advancements in these composite nanoparticles with prolamins derived from various cereals, including maize, wheat, sorghum, and millet, with a focus on their applications in oral drug delivery. It discusses the mechanisms by which these composites enhance nanoparticle performance, especially in terms of stability. The review also explores the differences among various prolamins and clarifies the reasons for their performance characteristics as encapsulants for nanoparticles. Additionally, it offers an in-depth examination of various preparation methods for these composite nanoparticles, such as the traditional anti-solvent method, pH-driven method, and several innovative techniques. The study highlights the physicochemical and encapsulation properties of these composite nanoparticles and underscores their novel applications, which hold promise for future use in the food and pharmaceutical sectors. The findings aim to support the integration of prolamin-polysaccharide composites into these industries, ultimately accelerating the development of new applications for these nanoparticles.
Competing Interests: Declaration of competing interest The authors report there are no competing interests to declare.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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