The possible role of hypoxia-induced exosomes on the fibroblast metabolism in idiopathic pulmonary fibrosis.

Autor: Alvarado-Vasquez N; Department of Molecular Biomedicine and Translational Research, National Institute of Respiratory Diseases 'Ismael Cosío Villegas', Mexico City 14080, Mexico., Rangel-Escareño C; Computational Genomics, National Institute of Genomic Medicine, Mexico City 14610, Mexico; School of Engineering and Sciences, Tecnologico de Monterrey, NL 64700, Mexico., de Jesús Ramos-Abundis J; National Institute of Psychiatry 'Ramón de la Fuente Muñiz', Mexico City 14370, Mexico., Becerril C; Department of Research in Pulmonary Fibrosis, National Institute of Respiratory Diseases 'Ismael Cosío Villegas', Mexico City 14080, Mexico., Negrete-García MC; Molecular Biology Laboratory, Department of Research in Pulmonary Fibrosis, National Institute of Respiratory Diseases 'Ismael Cosío Villegas', Mexico City 14080, Mexico. Electronic address: cristi.negrete@gmail.com.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Dec; Vol. 181, pp. 117680. Date of Electronic Publication: 2024 Nov 16.
DOI: 10.1016/j.biopha.2024.117680
Abstrakt: Idiopathic pulmonary fibrosis (IPF) has a high incidence and prevalence among patients over 65 years old. While its exact etiology remains unknown, several risk factors have recently been identified. Hypoxia is associated with IPF due to the abnormal architecture of lung parenchyma and the accumulation of extracellular matrix produced by activated fibroblasts. Exosomes play a crucial role in intercellular communication during both physiological and pathological processes, including hypoxic diseases like IPF. Recent findings suggest that a hypoxic microenvironment influences the content of exosomes in various diseases, thereby altering cellular metabolism. Although the role of exosomes in IPF is an emerging area of research, the significance of hypoxic exosomes as inducers of metabolic reprogramming in fibroblasts is still underexplored. In this study, we analyze and discuss the relationship between hypoxia, exosomal cargo, and the metabolic reprogramming of fibroblasts in the progression of IPF.
Competing Interests: Declaration of Competing Interest We have nothing to declare.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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