The preparation and evaluation of granulated chitosan-catechin tablets with excellent disintegration properties.

Autor: Adachi T; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan., Tomita Y; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan., Mizukai Y; Nippon Kayaku Food Techno Co., Ltd., 219, Iwahanamachi, Takasaki, Gunma, 370-1208, Japan., Maezaki Y; Nippon Kayaku Food Techno Co., Ltd., 219, Iwahanamachi, Takasaki, Gunma, 370-1208, Japan., Kawano K; Nippon Kayaku Food Techno Co., Ltd., 219, Iwahanamachi, Takasaki, Gunma, 370-1208, Japan., Commey KL; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan., Nakamura H; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan., Yamasaki K; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan., Otagiri M; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan., Anraku M; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan; DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan. Electronic address: anraku@ph.sojo-u.ac.jp.
Jazyk: angličtina
Zdroj: Carbohydrate research [Carbohydr Res] 2025 Jan; Vol. 547, pp. 109308. Date of Electronic Publication: 2024 Nov 08.
DOI: 10.1016/j.carres.2024.109308
Abstrakt: In this study, we prepared granulated chitosan (G-CS)/catechin tablets with excellent disintegration properties. We then compared their physical properties, dissolution behavior, and pharmacokinetic profile to non-granulated chitosan (N-CS)/catechin tablets. During the tableting process, the G-CS/catechin tablets demonstrated significantly higher compatibility and superior manufacturability, as evidenced by lower ejection and detachment stress than the N-CS/catechin tablets. This resulted in more robust tablets with better physical properties. The dissolution of catechin from the G-CS/catechin tablets occurred significantly faster than from the N-CS/catechin tablets, resulting in a significantly higher 2,2'-azino-bis(3 ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging capacity. Similarly, the primary catechin components of the tablets, epigallocatechin gallate (EGCG) and caffeine, showed faster dissolution and membrane uptake from the G-CS/catechin tablets. These indicate a more efficient tablet formulation than N-CS/catechin tablets. Furthermore, the absorption and bioavailability of EGCG and caffeine in rats were significantly higher after oral administration of the G-CS/catechin tablets than the N-CS/catechin tablets. These findings suggest that G-CS/catechin tablets, having better disintegration properties than N-CS/catechin tablets, could allow for combination with other supplements, leading to the design of highly efficient supplement combination tablets.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: