| Autor: |
Alasmari SM; Department of Biology, Faculty of Science and Arts, Najran University, 1988 Najran, Saudi Arabia., Albalawi AE; Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia., Alghabban AJ; Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia., Shater AF; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences. University of Tabuk, Saudi Arabia., Al-Ahmadi BM; Department of Biology, Faculty of Science, Taibah university, Kingdom of Saudi Arabia., Baghdadi HBA; Biology Department, College of Science, Imam Abdurrahman Bin Faisal University, Dammam 31441, Saudi Arabia., Almohammed HI; General Science Department, Deanship of Supportive Studies, Alasala University, P. O. Box 12666, Dammam 31483, Saudi Arabia. |
| Jazyk: |
angličtina |
| Zdroj: |
Tropical biomedicine [Trop Biomed] 2024 Sep 01; Vol. 41 (3), pp. 377-384. |
| DOI: |
10.47665/tb.41.3.019 |
| Abstrakt: |
Current strategies for tick control have led to the development of resistance and environmental contamination. Consequently, there is an urgent need for research into new and effective acaricides for tick control. The aim of this study was to fabricate and characterize Linalool loaded zinc oxide nanoparticles (Lin@ZNP), and to assess the acaricidal, larvacidal, and repellent activities of Lin@ ZNP against Hyalomma anatolicum, a prevalent tick species infesting cattle in Saudi Arabia. Lin@ ZNP was synthesized using an ethanolic solution of polyvinyl alcohol. The adult immersion, the larval packet, and the assessment of vertical movement behavior of tick larvae assays were utilized to examine the acaricidal, larvicidal, and repellent activities of Lin@ZNP against H. anatolicum, respectively. Furthermore, the impact of Lin@ZNP on acetylcholinesterase and oxidant/antioxidant enzyme activities was investigated. Exposure of adult H. anatolicum to different concentrations of Lin@ZNP resulted in noticeable (p<0.001) reductions in the viability rate of adults and the mean number, weight, and hatchability of eggs, compared to the control group. Lin@ZNP demonstrated significant repellent effects on H. anatolicum larvae after 60, 120, and 180 minutes of exposure. Lin@ZNP, particularly at all concentrations, markedly suppressed the acetylcholinesterase activity of the larval stage of H. anatolicum (P<0.001); but increase in malondialdehyde (MDA) levels (P<0.001) and a decrease in glutathione-S-transferase (GST) levels in H. anatolicum larvae (P<0.001). Lin@ZNP exhibited considerable acaricidal, larvicidal, and repellent effects against H. dromedarii adults and larvae in a manner dependent on the dosage. Additionally, Lin@ZNP notably reduced AChE levels and antioxidant activity, while inducing oxidative stress in H. anatolicum larvae. Nevertheless, further research is necessary to elucidate the precise mechanisms and practical efficacy of Lin@ZNP. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
