Incidence and prognosis of cutaneous melanoma in European adolescents and young adults (AYAs): EUROCARE-6 retrospective cohort results.

Autor: Indini A; Melanoma Unit, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Didoné F; Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. Electronic address: fabio.didone@istitutotumori.mi.it., Massi D; Section of Pathology, Department of Health Sciences, University of Florence, 50121 Florence, Italy., Puig S; Dermatology Department, Hospital Clínic Barcelona, IDIBAPS, Spain., Casadevall JR; Medical Oncology Department, Catalan Institute of Oncology, Girona, Spain., Bennett D; Northern Ireland Cancer Registry, Centre for Public Health, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Mulhouse Building, Grosvenor Road, Belfast, BT12 6DP Northern Ireland, UK., Katalinic A; University of Lübeck, Institute for Social Medicine and Epidemiology, Lübeck, Germany., Sanvisens A; Epidemiology Unit and Girona Cancer Registry, Institut Català d'Oncologia, Pla Director d'Oncologia, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI), 17004 Girona, Spain., Ferrari A; Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy., Lasalvia P; Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Demuru E; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Ragusa R; Catania-Messina-Enna CR, Azienda Ospedaliero Universitaria Policlinico, Catania, Italy., Mayer-da-Silva A; Southern Portugal Cancer Registry, Portuguese Oncology Institute of Lisbon Francisco Gentil, Lisbon, Portugal., Blum M; Eastern Switzerland Cancer Registry, St. Gallen, Switzerland., Mousavi M; Eastern Switzerland Cancer Registry, St. Gallen, Switzerland., Kuehni C; Cancer Registry, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Mihor A; Epidemiology and Cancer Registry, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia., Mandalà M; University of Perugia, Unit of Medical Oncology, Santa Maria Misericordia hospital, Perugia, Italy., Trama A; Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Jazyk: angličtina
Zdroj: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2024 Dec; Vol. 213, pp. 115079. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1016/j.ejca.2024.115079
Abstrakt: Background: Cutaneous melanoma (CM) is rare in adolescents and young adults (AYA, 15-39 years at cancer diagnosis) and studies on CM in AYAs are scarce. Our aim is to update CM incidence and survival in European AYAs and to compare incidence and survival both with other age groups and over time.
Methods: We used the EUROCARE-6 database (108 cancer registries; 29 EU countries), calculating incidence rates (IR) per 100,000 individuals/year in the European population (years of diagnosis: 2006-2013), 5-year relative survival (RS), and 5-year RS conditional to surviving the first year after diagnosis, for the follow-up period 2010-2014 (cases diagnosed in 2006-2013).
Results: The IR of CM in AYA was greater in females than in males, standing at 7. CM IR was higher in the limbs and lower in the head and neck (H&N) and trunk in females compared to males. Five-year RS was 94 % in AYA and 80 % in older age groups. Survival was higher in limb than in H&N and trunk CM. The incidence of CM increased more in older age groups than in AYA. CM survival rose over time for all ages.
Conclusions: Differences in IR between males and females may be due to different behaviors and CM biology. The increase in survival can be attributed to healthcare improvements, early diagnosis, and locoregional surgical treatments. The incidence trends are reassuring in terms of tumor burden in AYA. Our findings support the idea that CM is more aggressive with increasing age and gender differences partially explain survival differences between age groups.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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