IDH1/2 Mutations in Cancer: Unifying Insights and Unlocking Therapeutic Potential for Chondrosarcoma.

Autor: Deshmukh S; Department of Internal Medicine, The Ohio State University, Columbus, OH, USA., Kelly C; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tinoco G; Division of Medical Oncology, The Ohio State University, Columbus, OH, USA. Gabriel.Tinoco@osumc.edu.
Jazyk: angličtina
Zdroj: Targeted oncology [Target Oncol] 2024 Nov 15. Date of Electronic Publication: 2024 Nov 15.
DOI: 10.1007/s11523-024-01115-3
Abstrakt: Chondrosarcomas, a rare form of bone sarcomas with multiple subtypes, pose a pressing clinical challenge for patients with advanced or metastatic disease. The lack of US Food and Drug Administration (FDA)-approved medications underscores the urgent need for further research and development in this area. Patients and their families face challenges as there are no systemic therapeutic options available with substantial effectiveness. A significant number (50-80%) of chondrosarcomas have a mutation in the isocitrate dehydrogenase (IDH) genes. This review focuses on IDH-mediated pathogenesis and recent pharmacological advances with novel IDH inhibitors, explores their potential therapeutic value, and proposes potential future avenues for clinical trials combining IDH inhibitors with other systemic agents for chondrosarcomas.
Competing Interests: Declarations Funding No external funding was used in the preparation of this manuscript. Competing Interests C.K. and G.T. served on the advisory board for Servier in 2022. S.D. declares that they have no conflicts of interest that might be relevant to the contents of this manuscript. Ethics Approval & Consent to Participate Not applicable. Consent for Publication Not applicable. Availability of Data and Materials Not applicable Code availability Not applicable Authors’ Contributions S.D., C.K., and G.T. designed the review and wrote the manuscript. S.D. created Figs. 1 and 2.
(© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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