Prevalence of cardiometabolic outcomes in women who underwent salpingo-oophorectomy to prevent hereditary breast and ovarian cancer: a meta-analysis.

Autor: Moraes FCA; School of Medicine, Federal University of Pará, Belém, PA, 66073-005, Brazil. francisco.cezar2205@gmail.com., Moro LD; School of Medicine, Federal University of Pará, Belém, PA, 66073-005, Brazil., Souza MEC; Department of Medicine, University of Pernambuco, Recife, PE, 50670-901, Brazil., Rodrigues ALSO; Department of Medicine, University Center of João Pessoa, João Pessoa, PB, 58053-000, Brazil., Sano VKT; Department of Medicine, Federal University of Acre, Rio Branco, Acre, 69920900, Brazil., Barbosa BF; Department of Medicine, University of Aquino Bolivia, Santa Cruz de la Sierra, SC, 0701, Bolivia., Pacheco LG; School of Medicine, Federal University of Pará, Belém, PA, 66073-005, Brazil., Cunha DF; School of Medicine, Federal University of Pará, Belém, PA, 66073-005, Brazil., Queiroz OL; School of Medicine, State University of Pará, Marabá, PA, 68502-100, Brazil., Souza DDSM; Gaspar Vianna State Public Hospital of Clinical Foundation, Belém, PA, 66083-106, Brazil., Feio D; School of Medicine, Federal University of Pará, Belém, PA, 66073-005, Brazil., Stecca C; Mackenzie Evangelical University Hospital, Curitiba, Paraná, 80730-150, Brazil., Burbano RMR; Ophir Loyola Hospital, Belém, Pará, 66063-240, Brazil.
Jazyk: angličtina
Zdroj: Familial cancer [Fam Cancer] 2024 Nov 15; Vol. 24 (1), pp. 5. Date of Electronic Publication: 2024 Nov 15.
DOI: 10.1007/s10689-024-00431-x
Abstrakt: Risk reduction salpingo-oophorectomy (RRSO) is usually performed in women with hereditary breast and ovarian cancer (HBOC) syndrome for BRCA1 and BRCA2 gene mutation carriers, resulting in surgical menopause, which is more associated with a high risk of cardiovascular and metabolic disease than in premenopausal and natural menopausal women. This study assessed the prevalence of cardiovascular and metabolic outcomes in women who underwent salpingo-oophorectomy as a preventive measure against HBOC. This meta-analysis assessed prevalence rates for four metabolic/cardiovascular conditions: myocardial infarction, hypertension, hypercholesterolemia, and type 2 diabetes mellitus. DerSimonian and Laird random-effects models were applied to all analyses, with 95% confidence interval (CI). Heterogeneity was assessed with I². We used OpenMeta Analyst software for statistical analysis. A total of five retrospective studies and one observational study involving 1,320 patients were included. The average body mass index (BMI) was 25.97 kg/m2 and the average waist circumference was 87.94 cm. The analysis across a mean 4.94-year follow-up revealed prevalence rates for acute myocardial infarction of 1.5% (95% CI 0.3-2.7; P = 0.077; I²=56.25%), hypertension of 28% (95% CI 6.9-49.1; P < 0.001; I 2  = 98.42%), hypercholesterolemia of 27.2% (95% CI 6.8-47.6; P < 0.001; I²=98.67%), and type 2 diabetes mellitus of 3.3% (95% CI 1.1-5.5; P < 0.001; I²=82.44%). Our findings suggest that there is no marked increase in cardiovascular risk among women with HBOC undergoing RRSO.
Competing Interests: Declarations Institutional review board statement Not applicable. Informed consent Not applicable. Competing interests The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
Externí odkaz: