Chiral Self-Assembly of a Pyrene-Appended Glutamylalanine Dipeptide and Its Charge Transfer Complex: Fabrication of Magneto-Responsive Hydrogels and Human Cell Imaging.

Autor: Ruidas P; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Dubey SK; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Hafiz SA; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Mandal J; CIF Biophysical Laboratory, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, 700032, India., Mukherjee S; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Ghosh NN; Pakuahat A. N. M. High School, Malda, West Bengal, 732138, India., Midya R; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Roy D; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Das D; Department of Zoology, Sidho-Kanho-Birsha University, Purulia, West Bengal, 723104, India., Singh S; Indian Institute of Technology, Delhi, Sonipat Campus, Sonipat, Haryana, 131021, India., Neogi P; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Saha S; Department of Chemistry, Trivenidevi Bhalotia College, Raniganj, West Bengal, 713347, India., Roy UK; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Bhattacharyya S; Department of Zoology, Sidho-Kanho-Birsha University, Purulia, West Bengal, 723104, India., Ghosh A; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India., Bhattacharjee S; Department of Chemistry, Kazi Nazrul University, Asansol, West Bengal, 713340, India.
Jazyk: angličtina
Zdroj: Macromolecular rapid communications [Macromol Rapid Commun] 2024 Nov 15, pp. e2400672. Date of Electronic Publication: 2024 Nov 15.
DOI: 10.1002/marc.202400672
Abstrakt: The formation of a robust, self-healing hydrogel of a novel pyrene-appended dipeptide, Py-E-A (L-Glutamic acid short as E; L-Alanine short as A) is demonstrated. Detailed studies suggest that nanoscopic fibers with a length of several micrometers have formed by chiral self-organization of Py-E-A gelators. Additionally, live human PBMCs imaging is shown using the Py-E-A fluorophore. Interestingly, electron-rich Py-E-A couples with electron-deficient NDI-β-A (β-Alanine short as β-A) by charge transfer (CT) complexation and forms stable deep violet-colored CT super-hydrogel. X-ray diffraction, DFT, and 2D ROESY NMR studies suggest lamellar packing of both Py-E-A and the alternating CT stack in its hydrogel matrixes. Supramolecular chirality of the Py-E-A donor can be altered by adding an achiral acceptor NDI-β-A. Notably, the fibers of the CT hydrogel are found to be even thinner than the Py-E-A fibers, which, in turn, makes the CT hydrogel more tolerant to the applied strain. Further, the self-healing and injectable properties of the hydrogels are shown. Finally, the magneto-responsive behavior of the Py-E-A and CT hydrogels loaded with spin-canted Cu-ferrite (Cu 0.6 Zn 0.4 Fe 2 O 4 ) nanoparticles (NPs) is demonstrated. The presence of magnetic NPs within the hydrogels has changed the fibrous morphology to rod-like nanoclusters.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: