Treatment outcome in patients with spinal neurocysticercosis: a systematic review of published cases and case series.

Autor:	Garg RK; Department of Neurology, King George's Medical University, Lucknow, India., Rizvi I; Department of Neurology, King George's Medical University, Lucknow, India., Nigam H; Department of Neurology, King George's Medical University, Lucknow, India., Pandey S; Department of Neurology, King George's Medical University, Lucknow, India., Uniyal R; Department of Neurology, King George's Medical University, Lucknow, India.
Jazyk:	angličtina
Zdroj:	Future microbiology [Future Microbiol] 2024 Nov 15, pp. 1-12. Date of Electronic Publication: 2024 Nov 15.
DOI:	10.1080/17460913.2024.2428526
Abstrakt:	Aims: Spinal neurocysticercosis is a rare central nervous system infection caused by the larval form of the Taenia solium . Due to its rarity, most knowledge is derived from isolated case reports. This review aims to evaluate existing case reports and observational studies to provide a comprehensive overview of the disease's clinical presentation and treatment outcomes. Methods: Following PRISMA guidelines, a comprehensive search was performed across various databases. The review included case reports, case series, and observational studies, and it is registered with PROSPERO (CRD42024496957). Results: This review analyzed 206 spinal neurocysticercosis cases (from 171 published reports). Symptoms persisted for one week to six months in 49% of cases, and common presentations included paraparesis/quadriparesis (61.7%) and neck/limb/back pain (40.8%). CSF abnormalities were observed in 23.8%. Thoracic involvement was most frequent (39.3%), followed by cervical (27.2%). Neurocysticercosis lesions in other regions, primarily the brain, were found in 18.9%. Differential diagnoses included spinal cord tumors (13.1%). Treatment often involved surgery alone (32%) or with cysticidal drugs (45.6%), with a 91.3% improvement rate, indicating favorable outcomes. Conclusions: Spinal neurocysticercosis primarily affects the thoracic and cervical regions. Most patients respond well to medical therapy; surgery is mainly for progressive neurological deficits.
Databáze:	MEDLINE
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