Hydrogels in the clinic: An update.

Autor: Clegg JR; Stephenson School of Biomedical Engineering University of Oklahoma Norman Oklahoma USA.; Stephenson Cancer Center University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA.; Harold Hamm Diabetes Center University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA.; Institute for Biomedical Engineering, Science, and Technology University of Oklahoma Norman Oklahoma USA., Adebowale K; John A. Paulson School of Engineering and Applied Sciences Harvard University Allston Massachusetts USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University Boston Massachusetts USA., Zhao Z; Department of Pharmaceutical Sciences, College of Pharmacy University of Illinois at Chicago Chicago Illinois USA.; University of Illinois Cancer Center Chicago Illinois USA., Mitragotri S; John A. Paulson School of Engineering and Applied Sciences Harvard University Allston Massachusetts USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University Boston Massachusetts USA.
Jazyk: angličtina
Zdroj: Bioengineering & translational medicine [Bioeng Transl Med] 2024 May 16; Vol. 9 (6), pp. e10680. Date of Electronic Publication: 2024 May 16 (Print Publication: 2024).
DOI: 10.1002/btm2.10680
Abstrakt: Hydrogels have been used in the clinic since the late 1980s with broad applications in drug delivery, cosmetics, tissue regeneration, among many other areas. The past three decades have witnessed rapid advances in the fields of polymer chemistry, crosslinking approaches, and hydrogel fabrication methods, which have collectively brought many new hydrogel products, either injectable or non-injectable, to clinical studies. In an article published in 2020 entitled "Hydrogels in the clinic", we reviewed the clinical landscape and translational challenges of injectable hydrogels. Here, we provide an update on the advances in the field and also extend the scope to include non-injectable hydrogels. We highlight recently approved hydrogel products, provide an update on the clinical trials of injectable hydrogels, and discuss active clinical trials of topically applied and implantable hydrogels.
(© 2024 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.)
Databáze: MEDLINE
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