Comparative analyses of erythroblast transformation specific-1 related gene expression before and after neoadjuvant bevacizumab therapy for newly diagnosed glioblastoma.

Autor:	Iwauchi A; Department of Pathology, The Jikei University School of Medicine Tokyo, Japan., Fukasawa N; Department of Pathology, The Jikei University School of Medicine Tokyo, Japan., Takei J; Department of Neurosurgery, The Jikei University School of Medicine Tokyo, Japan., Maeda M; Department of Pathology, The Jikei University School of Medicine Tokyo, Japan., Tomoto K; Department of Neurosurgery, The Jikei University School of Medicine Kashiwa Hospital Tokyo, Japan., Teshigawara A; Department of Neurosurgery, The Jikei University School of Medicine Kashiwa Hospital Tokyo, Japan., Yamamoto Y; Department of Neurosurgery, The Jikei University School of Medicine Kashiwa Hospital Tokyo, Japan.; Department of Neurosurgery, The Jikei University School of Medicine Daisan Hospital Tokyo, Japan., Akasaki Y; Department of Neurosurgery, The Jikei University School of Medicine Tokyo, Japan., Hasegawa Y; Department of Neurosurgery, The Jikei University School of Medicine Kashiwa Hospital Tokyo, Japan., Murayama Y; Department of Neurosurgery, The Jikei University School of Medicine Tokyo, Japan., Miyake K; Department of Neurological Surgery, Faculty of Medicine, Kagawa University Graduate School of Medicine Tokyo, Japan., Shimoda M; Department of Pathology, The Jikei University School of Medicine Tokyo, Japan., Tanaka T; Department of Neurosurgery, The Jikei University School of Medicine Tokyo, Japan.; Department of Neurosurgery, The Jikei University School of Medicine Kashiwa Hospital Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2024 Oct 15; Vol. 17 (10), pp. 346-359. Date of Electronic Publication: 2024 Oct 15 (Print Publication: 2024).
DOI:	10.62347/GQWP4029
Abstrakt:	Objective: The aim of the present study was to investigate the expression of erythroblast transformation specific-1 related gene (ERG) in patients with glioblastoma (GB) before and after bevacizumab (Bev) therapy as a predictive and prognostic biomarker. Methods: The present study used 58 GB tissues from 29 patients in 3 settings. Sixteen tumors were removed after neoadjuvant Bev administration (neoBev) and 13 represented newly diagnosed GB without previous Bev treatment (naïve Bev). Another 29 specimens of recurrence were obtained from salvage surgery or autopsy. Results: Immunohistochemical analysis showed both vessel density (VD) and ERG score were decreased in neoBev compared with naïve Bev. VD and ERG score tended to be lower at recurrence than at initial surgery (P=0.0026 and P=0.1338, respectively). In the naïve Bev and neoBev cohorts, overall survival (OS) with high and low expressions of ERG was comparable (P=0.7516 and P=0.3862, respectively). Conclusion: High expression of ERG in GB with naïveBev was significantly reduced with Bev, but not changed in refractoriness. Stratification of ERG expression levels might provide a useful predictive biomarker for GB treated with Bev. Competing Interests: None. (IJCEP Copyright © 2024.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu