Let's focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders.

Autor:	Billaux P; Louvain Experimental Psychopathology Research Group (LEP), Psychological Science Research Institute, UCLouvain, Louvain-la-Neuve, Belgium., Segobin S; Normandie Université, UNICAEN, PSL Université Paris, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Caen, France., Maillard A; Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, APHP.NORD, Paris, France.; INSERM UMR-S 1144 Therapeutic Optimization in Neuropsychopharmacology, Université Paris Cité, Paris, France., Bloch V; INSERM UMR-S 1144 Therapeutic Optimization in Neuropsychopharmacology, Université Paris Cité, Paris, France.; FHU NOR-SUD (Network of Research in Substance Use Disorders), Paris, France.; Service de Pharmacie à Usage Interne, Hôpital Fernand Widal, APHP.NORD, Paris, France., Delmaire C; INSERM UMR-S 1144 Therapeutic Optimization in Neuropsychopharmacology, Université Paris Cité, Paris, France.; Service de Neuroradiologie, Fondation Ophtalmologique Rothschild, Paris, France., Cabé N; Normandie Université, UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging of Neurological Disorders', NeuroPresage Team, Cyceron, Caen, France.; Service d'Addictologie, Centre Hospitalier Universitaire de Caen, Caen, France., Laniepce A; Normandie Université, UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging of Neurological Disorders', NeuroPresage Team, Cyceron, Caen, France.; Normandie Université, UNIROUEN, CRFDP (EA7475), Rouen, France., Maurage P; Louvain Experimental Psychopathology Research Group (LEP), Psychological Science Research Institute, UCLouvain, Louvain-la-Neuve, Belgium., Poireau M; Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, APHP.NORD, Paris, France.; INSERM UMR-S 1144 Therapeutic Optimization in Neuropsychopharmacology, Université Paris Cité, Paris, France.; FHU NOR-SUD (Network of Research in Substance Use Disorders), Paris, France., Volle E; Sorbonne University, FrontLab at Paris Brain Institute (ICM), INSERM, CNRS, Paris, France., Vorspan F; Département de Psychiatrie et de Médecine Addictologique, Hôpital Fernand Widal, APHP.NORD, Paris, France.; INSERM UMR-S 1144 Therapeutic Optimization in Neuropsychopharmacology, Université Paris Cité, Paris, France.; FHU NOR-SUD (Network of Research in Substance Use Disorders), Paris, France., Pitel AL; Normandie Université, UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging of Neurological Disorders', NeuroPresage Team, Cyceron, Caen, France.; Institut Universitaire de France (IUF), France.
Jazyk:	angličtina
Zdroj:	European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2024 Nov 15; Vol. 67 (1), pp. e75. Date of Electronic Publication: 2024 Nov 15.
DOI:	10.1192/j.eurpsy.2024.1784
Abstrakt:	Background: Theoretical and empirical contributions have identified insula as key in addiction. However, anatomical modifications of the insula in addictive states, and their variations across substance use disorders (SUDs), remain to be specifically explored. We therefore explored the specificities and commonalities of insula gray matter (GM) alterations in severe alcohol use disorder (sAUD) and severe cocaine use disorder (sCUD). Methods: We explored insula GM volume through a refined parcellation in 12 subregions (six bilateral): anterior inferior cortex (AIC), anterior short gyrus, middle short gyrus, posterior short gyrus, anterior long gyrus (ALG), and posterior long gyrus (PLG). Using a linear mixed model analysis, we explored the insula volume profiles of 50 patients with sAUD, 61 patients with sCUD, and 36 healthy controls (HCs). Results: In both sAUD and sCUD, we showed overall insular lower volume with a right-sided lateralization effect, and a major volume deficit in bilateral ALG. Moreover, differences emerged across groups, with higher left AIC and PLG volume deficits in sCUD compared to sAUD and HC. Conclusions: We offered the first joint exploration of GM insular volumes in two SUD through refined parcellation, thus unveiling the similarities and dissimilarities in volume deficit profiles. Our results bring evidence complementing prior ones suggesting the core role of the right and posterior insula in craving and interoception, two crucial processes in addiction. Left AIC and PLG group differences also show that, while insula is a region of interest in SUD, sCUD and sAUD generate distinct insular profiles, which might parallel clinical differences across SUD.
Databáze:	MEDLINE
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