NEIVATECH pilot study: immersive virtual reality training in older amblyopic children with non-compliance or non-response to patching.

Autor: Leal-Vega L; Applied Clinical Neurosciences Research Group, Department of Medicine, Dermatology and Toxicology, University of Valladolid, Valladolid, 47005, Spain., Coco-Martín MªB; Applied Clinical Neurosciences Research Group, Department of Medicine, Dermatology and Toxicology, University of Valladolid, Valladolid, 47005, Spain. mbcoco@uva.es., Molina-Martín A; Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, 03016, Spain., Cuadrado-Asensio R; Institute of Applied Ophthalmobiology, University of Valladolid, Valladolid, 47011, Spain., Vallelado-Álvarez AI; Department of Ophthalmology, University Clinical Hospital, Valladolid, 47003, Spain., Sánchez-Tocino H; Department of Ophthalmology, Río Hortega University Hospital, Valladolid, 47012, Spain., Mayo-Íscar A; Institute for Research in Mathematics, University of Valladolid, Valladolid, 47011, Spain., Hernández-Rodríguez CJ; Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, 03016, Spain.; Department of Ophthalmology, Ribera Virgen de la Caridad Hospital, Cartagena, 30204, Spain., Arenillas Lara JF; Applied Clinical Neurosciences Research Group, Department of Medicine, Dermatology and Toxicology, University of Valladolid, Valladolid, 47005, Spain.; Department of Neurology, University Clinical Hospital, Valladolid, 47003, Spain., Piñero DP; Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, 03016, Spain.; Department of Ophthalmology, Vithas Medimar Hospital, Alicante, 03016, Spain.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 14; Vol. 14 (1), pp. 28062. Date of Electronic Publication: 2024 Nov 14.
DOI: 10.1038/s41598-024-79565-y
Abstrakt: Immersive virtual reality (VR) is recently being explored as a therapeutic alternative for the treatment of amblyopia. This pilot study aimed to evaluate the preliminary efficacy, safety, usability and satisfaction obtained with the use of a novel VR system (NEIVATECH) to provide binocular vision training in previously treated older amblyopic children with non-compliance or non-response to patching. A prospective, multicentre, open-label, single-arm, pilot study was conducted in which the intervention under study was 9 h of therapy with the NEIVATECH system, distributed in 18 half-hour sessions spread over 1 month. A comprehensive visual assessment was conducted before and after the intervention, and at the end of the intervention the safety and usability of the system and patient satisfaction were evaluated. After therapy, statistically significant differences were observed in the near best-corrected visual acuity (BCVA) of the dominant (p = 0.022) and non-dominant (p = 0.022) eye, in stereopsis based on the Binocular Function Score (p = 0.045) and in the break (p = 0.012) and recovery (p = 0.009) points of negative fusional vergence for distance vision. The safety and usability of the system and patient satisfaction with the therapy were adequate. These findings support further investigation of this treatment option in future studies incorporating a control group with which to compare the results obtained. Trial registration: NCT04819386.
Competing Interests: Declarations Competing interests The authors declare no competing interests. Ethics declarations This study has been conducted in accordance with the ethical principles for medical research involving human subjects of the Declaration of Helsinki and has been approved by the Drug Research Ethics Committee of the Valladolid East Health Area (Ref.: CASVE-NM-21-516). Prior to any testing and after explaining the possible consequences of the study, written informed consent was obtained from the parents or legal guardians of each child participating in the study.
(© 2024. The Author(s).)
Databáze: MEDLINE
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