Impact of resistant starch type 3 on fecal microbiota and stool frequency in Thai adults with chronic constipation randomized clinical trial.

Autor: Luk-In S; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand., Leepiyasakulchai C; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand. chaniya.lee@mahidol.ac.th., Saelee C; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand., Keeratichamroen A; Department of Community Nutrition, Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand., Srisangwan N; Department of Community Nutrition, Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand., Ponprachanuvut P; Department of Community Nutrition, Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand., Chammari K; Department of Community Nutrition, Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand., Chatsuwan T; Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.; Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Wannigama DL; Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.; Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Yamagata, Japan.; School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, WA, Australia.; Biofilms and Antimicrobial Resistance Consortium of ODA Receiving Countries, The University of Sheffield, Sheffield, UK.; Pathogen Hunter's Research Collaborative Team, Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Yamagata, Japan., Shein AMS; Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.; Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Kueakulpattana N; Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.; Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Srisakul S; Center of Excellence in Antimicrobial Resistance and Stewardship, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Multidisciplinary Program of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand., Sranacharoenpong K; Department of Health Development, ASEAN Institute for Health Development, Mahidol University, Nakhon Pathom, Thailand. kitti.sra@mahidol.ac.th.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 14; Vol. 14 (1), pp. 27944. Date of Electronic Publication: 2024 Nov 14.
DOI: 10.1038/s41598-024-79465-1
Abstrakt: Constipation poses a significant health concern affecting individuals of varying ages and geographic locations worldwide. While the impacts of numerous probiotics on constipation are well-characterized, there has been limited assessment of the potential prebiotic effects of resistant starches. We therefore conducted a randomized, double-blind and placebo-controlled, clinical trial of resistant starch type 3 (RS-3) in Thai adults with self-reported chronic constipation. The effects of these mixed natural starch fibers on beneficial gut bacteria, bowel movements and stool consistency were evaluated after 6- and 12-week periods. Regardless of subject age, consumption of RS-3 compared to placebo resulted in significant improvements in gut health by dramatically increasing levels of beneficial bacteria (Bifidobacterium, Prevotella, Akkermansia and Megamonas) in the gut and relieving constipation. RS-3 consumption was associated with a significantly increased frequency of bowel movements, with subjects reporting these as healthy stools. Our findings provide important insights into the therapeutic advantages of RS-3 for constipation, and propose RS-3 as a feasible alternative strategy for management of constipation.
Competing Interests: Declarations Competing interests The authors declare no competing interests. Ethics approval and consent to participate This study was conducted in accordance with the International Guidelines for Human Research Protection, including the Declaration of Helsinki, The Belmont Report, CIOMS Guidelines and the International Conference on Harmonization in Good Clinical Practice (ICH-GCP). The study protocol was approved by Mahidol University’s Central Institutional Review Board (Protocol No. MU-CIRB 2022/300.0711 and COA No. MU-CIRB 2023/004.0901). This study is registered in the NIH’s Protocol Registration and Results System (PRS) on their website (ClinicalTrials.gov ID: NCT06274242). All subjects provided written informed consent in compliance with the MU-CIRB informed consent guidelines.
(© 2024. The Author(s).)
Databáze: MEDLINE
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