The prospective associations of fetal growth-related pregnancy complications with subsequent breastfeeding duration and markers of human milk production.

Autor:	Pang WW; Global Center for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Bia-Echo Asia Centre for Reproductive Longevity and Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore. Electronic address: obgpww@nus.edu.sg., Geddes DT; School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia., Lai CT; School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia., Michael N; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore., Huang J; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore; Thompson School of Social Work and Public Health, Office of Public Health Studies, University of Hawai'i at Mānoa, Honolulu, HI, United States., Chan YH; Department of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore., Cheong CY; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore., Fok D; Department of Neonatology, National University Hospital and National University Health System, Singapore., Pundir S; Liggins Institute, University of Auckland, Auckland, New Zealand., Ng S; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore., Vickers MH; Liggins Institute, University of Auckland, Auckland, New Zealand., Chua MC; Department of Neonatology, KK Women's and Children's Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; School of Medicine, Duke-NUS, Singapore., Tan KH; School of Medicine, Duke-NUS, Singapore; Department of Maternal-Fetal Medicine, KK Women's and Children's Hospital, Singapore., Godfrey KM; Medical Research Council Lifecourse Epidemiology Unit Centre, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom., Shek LP; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Chong YS; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS) and National University Health System, Singapore., Eriksson JG; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore; Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS) and National University Health System, Singapore; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland., Chan SY; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore., Wlodek ME; School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A∗STAR), Singapore; Department of Obstetrics and Gynaecology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Victoria, Australia. Electronic address: m.wlodek@unimelb.edu.au.
Jazyk:	angličtina
Zdroj:	The American journal of clinical nutrition [Am J Clin Nutr] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.
DOI:	10.1016/j.ajcnut.2024.11.008
Abstrakt:	Background: The development of the breast for lactation occurs throughout pregnancy. It is unknown whether pregnancy complications resulting in poor fetal growth can affect breastfeeding (BF) success. Objectives: We examined whether fetal growth-related pregnancy complications were associated with earlier BF cessation and changes in the concentrations of human milk biomarkers of low milk production. Methods: We used data from the Growing Up in Singapore Toward healthy Outcomes study (n = 954). Human milk concentrations of protein, lactose, citrate, sodium, potassium, and zinc at 3 wk postpartum were available for 180 mother-infant dyads. We examined the associations of fetal growth measures, including term infants born small-for-gestational-age (SGA) (<10th percentile), pregnancies complicated by fetal growth deceleration (second to third trimester fetal growth dropped between major centiles), elevated umbilical artery resistance (>90th percentile) or hypertensive disorders of pregnancy (HDP) with 1) risk of ceasing BF (Cox regression) and 2) concentrations of human milk components (weighted linear regression). Results: Adjusting for maternal education, smoking exposure, BF intentions, and prepregnancy BMI (in kg/m 2 ), individuals who delivered SGA infants and those with HDP were more likely to breastfeed for a shorter duration when compared to those with uncomplicated pregnancies {adjusted hazard ratio [95% confidence interval (CI)]: 1.45 (1.11, 1.89) and 1.61 (1.14, 2.29), respectively}; associations were nonsignificant for fetal growth deceleration and umbilical artery resistance. SGA was not associated with concentrations of human milk biomarkers, but compared to participants with uncomplicated pregnancies, milk produced by those with HDP contained lower zinc concentrations [adjusted β coefficient (95% CI): -0.56 mg/L (-1.08, -0.04) mg/L]. Conclusions: Individuals with HDP and those with SGA infants tend to breastfeed for a shorter duration; however, only HDP appear to be associated with biomarkers of compromised milk production. Further research and support are needed to help individuals with HDP and SGA achieve their BF goals. This trial was registered at clinicaltrials.gov as NCT01174875. Competing Interests: Conflict of interest KMG, S-YC, and Y-SC are part of an academic consortium that has received research funding from Nestec Société Anonyme (SA). C-TL and DTG receive salaries from an unrestricted research grant from Medela Aktiengesellschaft (AG) administered by The University of Western Australia. All other authors report no conflicts of interest. (Copyright © 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu