Pregnant women's lifestyles and exposure to endocrine-disrupting chemicals: A machine learning approach.

Autor: Shah S; Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea., Oh J; Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea; Institute of Ewha-SCL for Environmental Health (IESEH), College of Medicine, Ewha Womans University, Seoul, Republic of Korea; Department of Human Systems Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea., Bang Y; Institute for Development and Human Security, Ewha Womans University, Seoul, Republic of Korea., Jung S; Department of Statistics, Ewha Womans University, Seoul, Republic of Korea., Kim HC; Department of Occupational and Environmental Medicine, College of Medicine, Inha University Hospital, Inha University, Incheon, Republic of Korea., Jeong KS; Department of Occupational and Environmental Medicine, College of Medicine, Wonju Severance Christian Hospital, Yonsei University, Wonju, Republic of Korea., Park MH; Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea., Lee KA; Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea., Ryoo JH; Department of Occupational and Environmental Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea., Kim YJ; Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea., Song S; Environmental Health Research Division, National Institute of Environmental Research, Incheon, Republic of Korea., Park H; Environmental Health Research Division, National Institute of Environmental Research, Incheon, Republic of Korea., Ha E; Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea; Institute of Ewha-SCL for Environmental Health (IESEH), College of Medicine, Ewha Womans University, Seoul, Republic of Korea; Graduate Program in System Health Science and Engineering, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. Electronic address: eunheeha@ewha.ac.kr.
Jazyk: angličtina
Zdroj: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2024 Nov 13; Vol. 366, pp. 125309. Date of Electronic Publication: 2024 Nov 13.
DOI: 10.1016/j.envpol.2024.125309
Abstrakt: Women have ubiquitous exposure to various endocrine disrupting chemicals (EDCs) present in personal care products, food packaging, and processing. Pregnancy is a phase of increased vulnerability to environmental stressors. Therefore, we aimed to identify questionnaire based variables of pregnant women's lifestyle factors affecting the prenatal concentrations of EDCs: bis-phenol A (BPA), triclosan (TCS), parabens, and phthalates. We also aimed to explore the association between these lifestyle factors and EDC exposure in pregnant women in South Korea. This study is a part of Korean CHildren's ENvironmental health Study (Ko-CHENS). The following lifestyle factors: usage of personal care products, eating habits, cooking practices, food storage practices, and chemical exposure were evaluated through questionnaire. We examined prenatal EDCs: phenols (BPA), TCS, parabens (MEP, ETP, and PRP), and phthalates (MEHHP, MEOHP, MECPP, MBZP, MCOP, MCPP, MCNP, and MNBP). The random forest and least absolute shrinkage and selection operator regression machine learning models were used to predict the important lifestyle factors affecting the prenatal EDC concentrations in pregnant women. Next, we calculated the lifestyle score and evaluated its association with prenatal EDCs, respectively. Our results show that pregnant women who used makeup [β: 1.01, 95% C.I.: 0.01,2.00] >6 times/week had a significant increase in early-pregnancy (EP) ΣParaben exposure. Using perfume up to 3 times/month was significantly associated with EP TCS exposure (β: 0.05, 95% C.I.: 0.01,0.23). While, using perfume >6 times/week was significantly associated to late-pregnancy (LP) ΣParaben exposure, and consuming cup noodles significantly increased LP ΣDEHP exposure. Linear model analysis showed that the lifestyle score significantly increased the EP (β: 0.24, 95% C.I.: 0.07,0.40) and LP (β:0.10, 95% C.I.: 0.01,0.20) ΣParaben exposure. Therefore, pregnant women's lifestyle factors, such as using makeup and perfume and eating habits (e.g., cup noodle consumption), were associated with prenatal EDC exposure.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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