Biodegradable stimulating electrodes for resident neural stem cell activation in vivo.

Autor: Chen T; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Lau KSK; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Singh A; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada., Zhang YX; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada., Taromsari SM; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada., Salari M; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada., Naguib HE; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Materials Science and Engineering, University of Toronto, Toronto, Ontario, Canada. Electronic address: naguib@mie.utoronto.ca., Morshead CM; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; CRANIA, University Health Network and University of Toronto, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address: cindi.morshead@utoronto.ca.
Jazyk: angličtina
Zdroj: Biomaterials [Biomaterials] 2024 Nov 09; Vol. 315, pp. 122957. Date of Electronic Publication: 2024 Nov 09.
DOI: 10.1016/j.biomaterials.2024.122957
Abstrakt: Brain stimulation has been recognized as a clinically effective strategy for treating neurological disorders. Endogenous brain neural precursor cells (NPCs) have been shown to be electrosensitive cells that respond to electrical stimulation by expanding in number, undergoing directed cathodal migration, and differentiating into neural phenotypes in vivo, supporting the application of electrical stimulation to promote neural repair. In this study, we present the design of a flexible and biodegradable brain stimulation electrode for temporally regulated neuromodulation of NPCs. Leveraging the cathodally skewed electrochemical window of molybdenum and the volumetric charge transfer properties of conductive polymer, we engineered the electrodes with high charge injection capacity for the delivery of biphasic monopolar stimulation. We demonstrate that the electrodes are biocompatible and can deliver an electric field sufficient for NPC activation for 7 days post implantation before undergoing resorption in physiological conditions, thereby eliminating the need for surgical extraction. The biodegradable electrode demonstrated its potential to be used for NPC-based neural repair strategies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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