Radiation adaptive response: the biophysical phenomenon and its theoretical description.

Autor:	Fornalski KW; Faculty of Physics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warszawa, Poland., Adamowski Ł; National Centre for Nuclear Research (NCBJ), ul. A. Sołtana 7, 05-400 Otwock-Świerk, Poland., Bugała E; Faculty of Physics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warszawa, Poland., Jarmakiewicz R; Faculty of Physics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warszawa, Poland., Krasowska J; Faculty of Physics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warszawa, Poland., Piotrowski Ł; Faculty of Physics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warszawa, Poland.
Jazyk:	angličtina
Zdroj:	Radiation protection dosimetry [Radiat Prot Dosimetry] 2024 Nov 13; Vol. 200 (16-18), pp. 1585-1589.
DOI:	10.1093/rpd/ncae053
Abstrakt:	The radiation adaptive response (or radioadaptation) effect is a biophysical and radiobiological phenomenon responsible for, e.g. the enhancement of repair processes, cell cycle and apoptosis regulation or enhancement of antioxidant production in cells/organisms irradiated by low doses and low dose-rates of ionising radiation. This phenomenon, however, is not always present, which creates many problems both for experimenters and theoreticians. Here we propose a comprehensive and complete theoretical model of radioadaptation grounded in mathematical concept of dose- and time-related probability function of the adaptive response appearance. This can be used in the context of two special cases of the adaptive response: the Raper-Yonezawa (priming dose) effect or constant low-dose-rate irradiation (e.g. for high natural background). This complete theoretical approach is supported by Monte Carlo simulations and real-experimental data used for model calibration and validation. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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