Possible existence of dose-rate threshold for mutation induction by chronic low-dose-rate gamma-rays.

Autor:	Nagashima H; Institute for Environmental Science, 1-7 Ienomae, Obuchi, Rokkasho, Kamikita, Aomori 039-3212, Japan., Komatsu K; Radiation Biology Center, Kyoto University, Yoshida-Konoe Cho, Sakyo-ku, Kyoto 606-8501, Japan., Tauchi H; Institute for Environmental Science, 1-7 Ienomae, Obuchi, Rokkasho, Kamikita, Aomori 039-3212, Japan.; Department of Biological Sciences, Ibaraki University, 2-1-1 Bunkyo, Mito, Ibaraki 310-8512, Japan.
Jazyk:	angličtina
Zdroj:	Radiation protection dosimetry [Radiat Prot Dosimetry] 2024 Nov 13; Vol. 200 (16-18), pp. 1615-1619.
DOI:	10.1093/rpd/ncae059
Abstrakt:	To assess the biological effects of low-dose and low-dose-rate radiation, we established a sensitive assay system for detecting somatic mutations in hypoxanthine-phosphoribosyltransferase 1 (HPRT1) gene. In this study, we investigated the dose-rate effects of mutagenesis by gamma irradiation at dose-rates of 6.6, 20 and 200 mGy d-1. We identified a potential inflection point in the gamma-induced mutant frequency, which ranged between 6.6 and 20 mGy d-1. In addition, the mutant spectrum was not different from that of the non-irradiated control at all dose-rates. Compared with previous studies with low-concentration HTO exposure, mutant frequencies were similar, but mutant spectrum showed different trends, especially at high-dose-rates (200 mGy d-1). These observations indicate the presence of potential mechanistic differences in mutagenic events between tritium beta and gamma-rays. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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