Factors affecting the polychlorinated biphenyl signatures in serum of adults living in a highly polluted area in eastern Slovakia.

Autor:	Hlisníková H; Department of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, Nitra, Slovakia., Kolena B; Department of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, Nitra, Slovakia., Trnovec T; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia., Richterová Bagratuni D; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia., Patayová H; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia., Čonka K; Department of Toxic Organic Pollutants, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia., Drobná B; Department of Toxic Organic Pollutants, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia., Rausová K; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia., Tihányi J; Institute of Health Protection, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia., Wimmerová S; Institute of Biophysics, Informatics and Biostatistics, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia., Petrovičová I; Department of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, Nitra, Slovakia., Nagyová M; Department of Zoology and Anthropology, Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, Nitra, Slovakia., Palkovičová Murínová Ľ; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2024 Oct 30; Vol. 12, pp. 1477692. Date of Electronic Publication: 2024 Oct 30 (Print Publication: 2024).
DOI:	10.3389/fpubh.2024.1477692
Abstrakt:	Introduction: Over the years eastern Slovakia has been subject to consistent monitoring of high levels of polychlorinated biphenyls (PCBs) in both the environment and human populations attributed to the former production of PCBs at the Chemko Strážske plant. We aimed to investigate the extent to which dietary habits and residential location could affect the concentrations of PCBs in the blood serum samples of subjects. Methods: We enrolled 602 adult subjects from eastern Slovakia with an average age of 45.14 (±8.49) years. To determine the concentrations of 21 PCB congeners, we used solid phase extraction along with gas chromatography coupled with high-resolution mass spectrometry. Based on questionnaire data, the assessment of dietary habits and residential location was performed using score calculations and creating a map. Results and Discussion: Through principal component analysis, the 20 PCB congeners were classified into three groups: PC1, comprising highly chlorinated PCBs, and PC2 and PC3, consisting primarily of low chlorinated PCBs. Stepwise multivariate regression revealed positive and negative associations between PCB congeners represented by PC1-3 and scores related to the residential location and scores related to food consumption, respectively. We confirmed that levels of PCBs represented by PC1-3 increased with age. The geographical proximity to pollution sources proved to be a key contributing factor to the observed PCB levels in individuals residing in eastern Slovakia. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Hlisníková, Kolena, Trnovec, Richterová Bagratuni, Patayová, Čonka, Drobná, Rausová, Tihányi, Wimmerová, Petrovičová, Nagyová and Palkovičová Murínová.)
Databáze:	MEDLINE
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