Navigating Therapeutic Challenges of Pyoderma Gangrenosum in Felty's Syndrome: A Case Report and Literature Review.
| Autor: | Acuña-Rocha VD; Internal Medicine, Hospital Universitario Dr. José Eleuterio González, Monterrey, MEX., Sanchez Solís G; Internal Medicine, Hospital Universitario Dr. José Eleuterio González, Monterrey, MEX., Ramírez-Vázquez JA; Internal Medicine, Hospital Universitario Dr. José Eleuterio González, Monterrey, MEX., Fischer Rouyer A; Internal Medicine, Hospital Universitario Dr. José Eleuterio González, Monterrey, MEX., Hernández Galarza IJ; Rheumatology, Hospital Universitario Dr. José Eleuterio González, Monterrey, MEX. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Oct 14; Vol. 16 (10), pp. e71428. Date of Electronic Publication: 2024 Oct 14 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.71428 |
| Abstrakt: | Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by painful skin ulcers. Treatment typically involves systemic corticosteroids, calcineurin inhibitors, or tumor necrosis factor-alpha inhibitors. Currently, treatment guidelines are not well established, making it important to consider alternative options in complicated cases. We report the case of a 52-year-old female with rheumatoid arthritis (RA) and a history of Felty's syndrome (FS) who developed PG and subsequently developed neutropenia due to azathioprine. The patient achieved remission with the use of dapsone and filgrastim. This treatment may be effective as an alternative for patients with RA and FS. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Acuña-Rocha et al.) |
| Databáze: | MEDLINE |
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