Musculoskeletal infections associated with Nocardia species: a case series.

Autor:	Khodadadi RB; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., McHugh JW; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Chesdachai S; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Wengenack NL; Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA., Bosch W; Division of Infectious Diseases, Mayo Clinic, Jacksonville, Florida, USA., Seville MT; Division of Infectious Diseases, Mayo Clinic, Phoenix, Arizona, USA., Osmon DR; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA., Beam E; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Yetmar ZA; Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio, USA.
Jazyk:	angličtina
Zdroj:	Journal of bone and joint infection [J Bone Jt Infect] 2024 Sep 24; Vol. 9 (5), pp. 207-212. Date of Electronic Publication: 2024 Sep 24 (Print Publication: 2024).
DOI:	10.5194/jbji-9-207-2024
Abstrakt:	Background : Nocardia is an uncommon pathogen that has been reported to infect musculoskeletal structures. However, studies are largely limited to case reports, and little is known regarding management and outcomes of these infections. Methods : We performed a multicenter retrospective cohort study of adults with culture-confirmed musculoskeletal Nocardia infections at three Mayo Clinic centers in Arizona, Florida, and Minnesota from November 2011 through April 2022. Results : Nine cases of Nocardia musculoskeletal infection were identified. Seven (78 %) occurred in men, and the median age was 57.3 years (range 32.6-79.0). Specific infections included native joint septic arthritis with or without associated osteomyelitis ( N = 3 ), hardware-associated infection ( N = 1 ), sternal osteomyelitis ( N = 1 ), pyomyositis ( N = 2 ), bursitis ( N = 1 ), and tenosynovitis ( N = 1 ). Three cases (33 %) were associated with disseminated disease, all three occurring in solid organ transplant recipients. Surgical intervention was performed in all but the bursitis case. Length of treatment varied from 21 d for tenosynovitis to 467 d for osteomyelitis. The 1-year mortality was 22 %, and all fatal cases involved disseminated disease. Conclusion : Patients with localized nocardiosis affecting musculoskeletal structures generally have good outcomes, as opposed to those with disseminated infection. Management often required operative intervention, with one patient experiencing recurrence within 1 year. Competing Interests: The contact author has declared that none of the authors has any competing interests. (Copyright: © 2024 Ryan B. Khodadadi et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu