A guideline on biomarkers in the diagnosis and evaluation in axial spondyloarthritis.

Autor:	Liu D; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Xie Y; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Tu L; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Wen X; Department of Rheumatology, Shenzhen Longhua District Central Hospital, Shenzhen, China.; Shenzhen Longhua Institute of Immunology Transformation, Shenzhen, China., Lv Q; Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China., Liu B; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Yang M; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Wu X; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Zheng X; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Luo X; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Zhou L; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Wu J; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Liu B; Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Wang K; Department of Joint Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Jin O; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Wang X; Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Qin J; Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Wu L; Department of Rheumatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, China., Zhao D; Department of Rheumatology, Changhai Hospital, Shanghai, China., He D; Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., He S; Department of Rheumatology, Zhongshan City People's Hospital, Zhongshan, China., Huang W; Department of Rheumatology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Ye S; Department of Rheumatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhou H; Department of Rheumatology, The Fourth Central Hospital Chinese PLA Medical School, Xi'an, China., Wu J; Department of Rheumatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China., Wang Y; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou, China., Liu S; Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Li Z; Department of Rheumatology, Bethune International Peace Hospital, Shijiazhuang, China., Tan Z; Department of Rheumatology, Huizhou Central Hospital, Huizhou, China., Xu C; Department of Rheumatology, The Second People's Hospital of Shenzhen City, Shenzhen, China., Wang Y; Department of Rheumatology, Jiangxi Province People's Hospital, Nanchang, China., Zheng D; Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Zhan F; Department of Nephropathy and Rheumatology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China., Lin C; Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China., Wen Y; Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China., Wu J; Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China., Wen S; Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China., Liao Z; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Shen Y; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing, China., Yang K; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China., Gu J; Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.; Shenzhen Longhua Institute of Immunology Transformation, Shenzhen, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Oct 30; Vol. 15, pp. 1394148. Date of Electronic Publication: 2024 Oct 30 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1394148
Abstrakt:	Objective: To develop a guideline for selecting biomarkers in the diagnosis and assessment in patients with axial spondyloarthritis (axSpA). Method: A joint effort was carried out by the core team, the literature review team and the multidisciplinary voting panel to formulate recommendations regarding biomarkers in axSpA, using an evidence-based and consensus-based strategy. Certainty of evidence and strength of recommendation were determined, and levels of agreement within the voting panel were calculated. Results: A total of 20 recommendations were formulated in this guideline, with levels of agreement ranging from 6.48 to 9.71. The two strong recommendations, HLA-B27 testing in patients suspected of axSpA and regular-interval monitoring of CRP/ESR represent the status quo of axSpA evaluation, while the 13 conditional recommendations represent the promising biomarkers with clinical utility in diagnosis, disease activity assessment, prediction of radiographic progression and therapeutic responses. This guideline does not dictate clinical choices of tests on axSpA, and decisions should be made based on comprehensive consideration of costs, accessibility, patients' values and willingness as well as the objective of testing in the local context. Conclusion: This guideline addresses the interpretation of the clinical significance of biomarkers in axSpA, and the biomarkers endorsed in this guideline composed a clinical toolkit for healthcare professionals to choose from. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Liu, Xie, Tu, Wen, Lv, Liu, Yang, Wu, Zheng, Luo, Zhou, Wu, Liu, Wang, Jin, Wang, Qin, Wu, Zhao, He, He, Huang, Ye, Zhou, Wu, Wang, Liu, Li, Tan, Xu, Wang, Zheng, Zhan, Lin, Wen, Wu, Wen, Liao, Shen, Yang and Gu.)
Databáze:	MEDLINE
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