Mild boroxazolidone formation and dissociation: application toward target identification of bioactive molecules.

Autor:	Tabei T; School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. saito-y@staff.kanazawa-u.ac.jp., Nakagawa-Goto K; School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. saito-y@staff.kanazawa-u.ac.jp.; Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, USA., Saito Y; School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. saito-y@staff.kanazawa-u.ac.jp.; Advanced Preventive Medical Sciences Research Center, Kanazawa University, Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.
Jazyk:	angličtina
Zdroj:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Nov 28; Vol. 60 (96), pp. 14252-14255. Date of Electronic Publication: 2024 Nov 28.
DOI:	10.1039/d4cc05370b
Abstrakt:	We successfully found that boroxazolidone can dissociate under aqueous conditions, which were applicable to a solution containing proteins. The immobilization of a newly synthesized diarylborinic acid on beads enabled the capture and release of target proteins of bioactive compounds through boroxazolidone formation and dissociation.
Databáze:	MEDLINE
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