Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model.

Autor: Alhaddad R; Pharmacological & Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan., Abualsoud BM; Pharmacological & Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan., Al-Deeb I; Pharmacological & Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan.; Department of Clinical Pharmacy, Faculty of Pharmacy, Zarqa University, Zarqa, 13110, Jordan., Nsairat H; Pharmacological & Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan.
Jazyk: angličtina
Zdroj: Future science OA [Future Sci OA] 2024 Dec 31; Vol. 10 (1), pp. 2419806. Date of Electronic Publication: 2024 Nov 14.
DOI: 10.1080/20565623.2024.2419806
Abstrakt: Aim: ZnO NPs were prepared via green synthesis utilizing Zingiber Officinale . Methodology: Physical characterization and biological activity were performed against 2D, and 3D spheroids MCF-7 cell lines. Results: The NPs exhibited 188.9, 175.7 and 171.2 nm size with charge of -8.2, -11.7 and -9.7 mV for the 2%, 3% and 4% formulations. XRD confirmed a wurtzite hexagonal phase. FTIR spectra showed Zn-O stretching vibrations. The 2%, 3% and 4% formulations presented IC 50 values of 14.7, 26.2 and 47 μg/ml, respectively, with complete destruction of MCF-7 spheroids. Elevated TNF-α levels suggested an inflammatory-mediated mechanism of action. Conclusion: 2% Zingiber officinale -derived ZnO NPs showed antitumor potential against deserving further mechanistic and in vivo explorations.
Databáze: MEDLINE