Entrainment of neural oscillations during language processing in Early-Stage schizophrenia.

Autor:	Grent-'t-Jong T; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany., Dheerendra P; School of Psychology and Neuroscience, University of Glasgow, UK., Fusar-Poli P; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, King's College London, UK; Department of Brain and Behavioral Sciences, University of Pavia, Italy; Outreach and Support in South-London (OASIS) service, South London and Maudlsey (SLaM) NHS Foundation Trust, UK; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University (LMU), Munich, Germany., Gross J; Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Muenster, Germany., Gumley AI; Institute of Health and Wellbeing, Univ. of Glasgow, UK., Krishnadas R; Dept. of Psychiatry, Univ. of Cambdrige, Cambridge, UK., Muckli LF; School of Psychology and Neuroscience, University of Glasgow, UK., Uhlhaas PJ; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany; School of Psychology and Neuroscience, University of Glasgow, UK. Electronic address: peter.uhlhaas@charite.de.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2024 Oct 28; Vol. 44, pp. 103695. Date of Electronic Publication: 2024 Oct 28.
DOI:	10.1016/j.nicl.2024.103695
Abstrakt:	Background: Impairments in language processing in schizophrenia (ScZ) are a central aspect of the disorder but the underlying pathophysiology mechanisms are unclear. In the current study, we tested the hypothesis that neural oscillations are impaired during speech tracking in early-stage ScZ and in participants at clinical high-risk for psychosis (CHR-P). Method: Magnetoencephalography (MEG) was used in combination with source reconstructed time-series to examine delta and theta-band entrainment during continuous speech. Participants were presented with a 5-minute audio recording during which they either attened to the story or word level. MEG-data were obtained from n = 22 CHR-P participants, n = 23 early-stage ScZ-patients, and n = 44 healthy controls (HC). Data were analysed with a Mutual Information (MI) approach to compute statistical dependence between the MEG and auditory signal, thus estimating individual speech-tracking ability. MEG-activity was reconstructed in a language network (bilateral inferior frontal cortex [F3T; Broca's], superior temporal areas [STS3, STS4; Wernicke's areas], and primary auditory cortex [bilateral HES; Heschl's gyrus]). MEG-data were correlated with clinical symptoms. Results: Theta-band entrainment in left Heschl's gyrus, averaged across groups, was significantly lower in the STORY compared to WORD condition (p = 0.022), and averaged over conditions, significantly lower in CHR-Ps (p = 0.045), but intact in early ScZ patients (p = 0.303), compared to controls. Correlation analyses between MEG data and symptom indicated that lower theta-band tracking in CHR-Ps was linked to the severity of perceptual abnormalities (p = 0.018). Conclusion: Our results show that CHR-P participants involve impairments in theta-band entrainment during speech tracking in left primary auditory cortex while higher-order speech processing areas were intact. Moreover, the severity of aberrant perceptual experiences in CHR-P participants correlated with deficits in theta-band entrainment. Together, these findings highlight the possibility that neural oscillations during language processing could reveal fundamental abnormalities in speech processing which may constitute candidate biomarkers for early detection and diagnosis of ScZ. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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