Step-wise reproductive toxicities of imidazolium- and pyridinium-based ionic liquids on Caenorhabditis elegans.

Autor: Zhang J; College of Ecological Technology and Engineering, Shanghai Institute of Technology, Shanghai 201418, PR China. Electronic address: zhjshy@163.com., Lv C; College of Ecological Technology and Engineering, Shanghai Institute of Technology, Shanghai 201418, PR China; Jiaxing Tongji Institute for Environment, Jiaxing, Zhejiang 314051, PR China., Yu Z; Jiaxing Tongji Institute for Environment, Jiaxing, Zhejiang 314051, PR China; College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China., Zhou Y; Jiaxing Tongji Institute for Environment, Jiaxing, Zhejiang 314051, PR China.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2024 Dec 05; Vol. 480, pp. 136458. Date of Electronic Publication: 2024 Nov 08.
DOI: 10.1016/j.jhazmat.2024.136458
Abstrakt: Reproductive toxicities of imidazolium- ([EMIM]X) and pyridinium-based ([APYR]X) ionic liquids (ILs) are essential to fully assess their hazards. Presently, effects of five ILs on the intricate processes of reproduction, including sperm-oocyte interactions, were explored in Caenorhabditis elegans. Results showed that 1-ethylpyridinium bromide ([EPYR]Br) stimulated oocytes, zygotes and total reproduction. 1-Octylpyyridinium bromide ([OPYR]Br) inhibited oocytes and stimulated zygotes, it inhibited the initial and total reproduction. 1-Dodecylpyridinium bromide ([DPYR]Br) inhibited oocytes and zygotes, but stimulated the initial and total reproduction. 1-Ethyl-3-methylimidazolium bromide ([EMIM]Br) inhibited oocytes, but stimulated zygotes and reproduction. 1-Ethyl-3-methylimidazolium iodide ([EMIM]I) inhibited germcells and oocytes but stimulated zygotes and reproduction. Regarding hormones and lipid metabolism, the ILs commonly reduced main sperm protein, sperm transmembrane protein 9 and spermatocyte protein 8. The qRT-PCR results showed that the ILs commonly down-regulated the expressions of mpk-1, while up-regulated those of inx-14, with influences on the expressions of vab-1, unc-43 and rme-2. These biochemicals and genes were directly connected with the sperm-oocyte interactions. Transcriptomic analysis results supported the involvement of cAMP and cGMP-PKG signaling pathways underlying the effects on the sperm-oocyte interactions. The results also implied ILs' impacts on neural and immune diseases and even cancers that should be considered in the future.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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