Risk of severe influenza infection in women with a history of pregnancy complications: A longitudinal cohort study.

Autor: Amer A; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada., Ayoub A; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.; Institut national de Santé Publique du Québec, Montreal, Quebec, Canada., Brousseau É; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.; Institut national de Santé Publique du Québec, Montreal, Quebec, Canada., Auger N; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada.; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada.; Institut national de Santé Publique du Québec, Montreal, Quebec, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Nov 13; Vol. 19 (11), pp. e0313653. Date of Electronic Publication: 2024 Nov 13 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0313653
Abstrakt: Background: Risk factors for influenza complications in women are poorly understood. We examined the association between pregnancy outcomes and risk of influenza hospitalization up to three decades later.
Methods: We analyzed a cohort of 1,421,531 pregnant women who delivered in Quebec, Canada between 1989 and 2021. Patients were followed over time beginning at the first delivery. The main exposure measures included obstetric complications such as preeclampsia, gestational diabetes, and preterm birth. The main outcome was influenza hospitalization up to 32 years later. We used adjusted Cox regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between obstetric complications and risk of influenza hospitalization following pregnancy.
Results: A total of 4,016 women were hospitalized for influenza during 32 years of follow-up. Influenza hospitalization was more frequent among women with pregnancy complications than women without complications (18.0 vs 14.1 per 100,000 person-years). Compared with no pregnancy complication, women with gestational diabetes (HR 1.48, 95% CI 1.30-1.69), preeclampsia (HR 1.45, 95% CI 1.28-1.65), placental abruption (HR 1.36, 95% CI 1.12-1.66), preterm birth (HR 1.40, 95% CI 1.27-1.55), cesarean section (HR 1.22, 95% CI 1.13-1.31), and severe maternal morbidity (HR 1.43, 95% CI 1.22-1.68) had a greater risk of influenza hospitalization later in life. These pregnancy outcomes were associated with severe influenza infections requiring critical care.
Conclusions: Women with pregnancy complications have an elevated risk of severe influenza complications later in life and have potential to benefit from seasonal vaccination to prevent influenza hospitalization.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Amer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz: