Familial risk of sinus node dysfunction indicating pacemaker implantation: a nationwide cohort study.

Autor:	Christiansen MK; Department of Cardiology, Viborg Regional Hospital, Heibergs alle 2K, DK-8800 Viborg, Denmark.; Department of Clinical Medicine, Health, Aarhus University, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus N, Denmark., Parner ET; Department of Public Health, Section of Biostatistics, Aarhus University, Aarhus, Denmark., Johansen JB; Department of Cardiology, Odense University Hospital, Odense, Denmark., Nielsen JC; Department of Clinical Medicine, Health, Aarhus University, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus N, Denmark.; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Jensen HK; Department of Clinical Medicine, Health, Aarhus University, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus N, Denmark.; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Jazyk:	angličtina
Zdroj:	Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology [Europace] 2024 Dec 03; Vol. 26 (12).
DOI:	10.1093/europace/euae287
Abstrakt:	Aims: We aimed to investigate the risk of sinus node dysfunction (SND) indicating cardiac pacing and mortality in first-degree relatives to patients with a pacemaker implanted on this indication and assess the effect of onset-age on disease risk. Methods and Results: In this nationwide register-based study, we used the Danish Civil Registration Registry to establish family structures and merged data with the Danish National Patient Registry and the Danish Pacemaker and ICD Registry containing information on all pacemakers implanted due to SND in Denmark. We followed 6 027 090 individuals born after 1954 in the period between 1982 and 2022 (180 775 041 person-years) among whom 2.477 pacemakers were implanted due to SND. The adjusted rate ratio (RR) of pacemaker-treated SND was 2.9 (2.4-3.6) for individuals having any father, mother, or sibling with a pacemaker implanted on this indication compared with the general population (derived cumulative incidence at the age of 68 years: 0.79 and 0.27%, respectively). This risk was inversely proportional to implantation age in the index person [≤60 years: RR = 5.5 (3.4-9.0)]. Overall, mortality was similar between individuals having a father, mother, or sibling with SND and the general population, but higher for relatives to index persons with an early onset [≤60 years: RR = 1.22 (1.05-1.41)]. Conclusion: First-degree relatives to SND patients are at increased risk of SND with risk being inversely associated with pacemaker implantation age in the index person. Mortality in first-degree relatives was comparable with the general population, although subgroup findings suggest an increased mortality among individuals with a family history of early-onset SND. Competing Interests: Conflict of interest: M.K.C. received consultant fees from Amgen Inc. outside this work. J.C.N. received research grants from the Novo Nordisk Foundation and the Danish Heart Foundation outside this work. H.K.J. received research grants from the Novo Nordisk Foundation (NNF18OC0031258 and NNF20OC006551) outside this work, and lecture fees from Abbott Denmark, Amgen Denmark, and Biosense Webster, Europe. The remaining authors have nothing to disclose. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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