Exposure to Volatile Organic Compounds and Blood Pressure in NHANES 2011 to 2018.

Autor:	McGraw KE; Department of Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY. (K.E.M., A.D.-R., D.N.M., T.R.S.)., Domingo-Relloso A; Department of Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY. (K.E.M., A.D.-R., D.N.M., T.R.S.)., Riggs DW; Christina Lee Brown Envirome Institute, University of Louisville, KY (D.W.R.)., Medgyesi DN; Department of Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY. (K.E.M., A.D.-R., D.N.M., T.R.S.)., Neupane R; Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL (R.N.)., Stingone JA; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY. (J.A.S.)., Sanchez TR; Department of Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY. (K.E.M., A.D.-R., D.N.M., T.R.S.).
Jazyk:	angličtina
Zdroj:	Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.
DOI:	10.1161/HYPERTENSIONAHA.124.23695
Abstrakt:	Background: Volatile organic compounds (VOCs) are ubiquitous environmental pollutants. Exposure to VOCs is associated with cardiovascular disease risk factors, including elevated blood pressure in susceptible populations. However, research in the general population, particularly among nonsmoking adults, is limited. We hypothesized that higher VOC exposure is associated with higher blood pressure and hypertension, among nonsmokers. Methods: We included 4 cycles of data (2011-2018) of nonsmoking adults (n=4430) from the National Health and Nutrition Examination Survey. Urinary VOC metabolites were measured by ultraperformance liquid chromatography-mass spectrometry, adjusted for urine dilution, and log-transformed. We estimated mean differences in blood pressure using linear models and prevalence ratio of stage 2 hypertension using modified Poisson models with robust standard errors. Models were adjusted for age, sex, race and ethnicity, education, body mass index, estimated glomerular filtration rate, and National Health and Nutrition Examination Survey cycle. Results: Participants were 54% female, with a median age of 48 years, 32.3% had hypertension, and 7.9% had diabetes. The mean differences (95% CI) in systolic blood pressure were 1.61 (0.07-3.15) and 2.46 (1.01-3.92) mm Hg when comparing the highest with the lowest quartile of urinary acrolein (N-acetyl-S-[2-carboxyethyl]-L-cysteine) and 1,3-butadiene (N-acetyl-S-[3,4-dihydroxybutyl]-L-cysteine) metabolites. The prevalence ratios for hypertension were 1.06 (95% CI, 1.02-1.09) and 1.05 (95% CI, 1.01-1.09) when comparing the highest with lowest quartiles of urinary acrolein (N-acetyl-S-[2-carboxyethyl]-L-cysteine) and 1,3-butadiene (N-acetyl-S-[3,4-dihydroxybutyl]-L-cysteine), respectively. Conclusions: Exposure to VOCs may be a relevant yet understudied environmental contributor to cardiovascular disease risk in the nonsmoking, US population.
Databáze:	MEDLINE
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