Harnessing the power of Calculus bovis : Anti-cancer properties and Wnt pathway modulation in hepatocellular carcinoma.

Autor:	Goyal H; Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India., Parwani S; Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India., Fatima K; Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India., Kaur J; Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. jyotdeep2001@yahoo.co.in.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2024 Nov 07; Vol. 30 (41), pp. 4496-4502.
DOI:	10.3748/wjg.v30.i41.4496
Abstrakt:	In this manuscript, we comment on the article, which explores the anti-cancer effects of Calculus bovis (CB) in tumor biology. We highlight its potential, particularly in hepatocellular carcinoma (HCC), where it inhibits the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways and induces apoptosis. CB contains compounds such as oleanolic acid and ursolic acid that target interleukin-6, mitogen-activated protein kinase 8, vascular endothelial growth factor, and caspase-3, offering anti-inflammatory and hepatoprotective benefits. The manuscript also discusses CB sativus (CBS), an artificial substitute, which has shown efficacy in reducing hepatic inflammation and oxidative stress in animal models. We emphasize the need for further research on the effects of CBS on the gut-liver axis and gut microbiota, and on targeting Wnt signaling and M2 tumor-associated macrophage as potential therapeutic strategies against HCC. Competing Interests: Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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